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Ivosidenib

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Ivosidenib Basic information

Product Name:
Ivosidenib
Synonyms:
  • AG120;AG 120
  • RG120
  • Ivosidenib
  • CS-1721
  • lvosidenib
  • RG120 100MG
  • EOS-60845
  • Ivosidenib(AG-120)
CAS:
1448347-49-6
MF:
C28H22ClF3N6O3
MW:
582.96
Product Categories:
  • API
Mol File:
1448347-49-6.mol
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Ivosidenib Chemical Properties

Melting point:
151-173°C
Boiling point:
854.3±65.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
11.58±0.40(Predicted)
form 
Solid
color 
White to Off-White
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Ivosidenib Usage And Synthesis

Description

AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate. AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.

Uses

Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers.

Definition

ChEBI: Ivosidenib is a tertiary carboxamide resulting from the formal condensation of the carboxy group of (2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylic acid with the secondary amino group of (2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-[(5-fluoropyridin-3-yl)amino]acetamide. It is approved by the FDA for the treatment of acute myeloid leukemia (AML) in patients with an isocitrate dehydrogenase-1 (IDH1) mutation. It has a role as an antineoplastic agent and an EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor. It is a member of monochlorobenzenes, a cyanopyridine, a member of pyrrolidin-2-ones, an organofluorine compound, a tertiary carboxamide and a secondary carboxamide.

in vitro

tf-1 cells or primary human aml patient samples expressing mutant idh1 were treated with ag-120, and the results showed that in tf-1 idh1-r132h cells, ag-120 was able to decrease the intracellular 2-hg levels, inhibit growth factor independent proliferation and restore erythropoietin-induced differentiation [1].

IC 50

< 100 nm

storage

Store at -20°C

References

[1] erica hansen et al. ag-120, an oral, selective, first-in-class, potent inhibitor of mutant idh1, reduces intracellular 2hg and induces cellular differentiation in tf-1 r132h cells and primary human idh1 mutant aml patient samples treated ex vivo. blood 2014 124:3734.
[2] http://www. aacr.org/newsroom/pages/news-release-detail.aspx itemid=789#.wlauom997iu

IvosidenibSupplier

Anqing Benro pharmachem Technology Co.,Ltd. Gold
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05565209906 15391842992
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Shanghai Hope Chem Co., Ltd., Gold
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Wuhan Shanhai Zhihe Biotechnology Co., Ltd. Gold
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15869524721
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Changzhou Borl Biotechnology Co.,LTD Gold
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13606124132;13656121842
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