Hydroxy-PEG4-t-butyl ester
Hydroxy-PEG4-t-butyl ester Basic information
- Product Name:
- Hydroxy-PEG4-t-butyl ester
- Synonyms:
-
- HO-PEG4-CH2CH2COOTBU
- Hydroxy-PEG-5-t-butyl ester
- PEG5-t-butly ester
- Hydroxy-PEG4-t-butly ester
- OH-PEG4-CH2CH2COOtBu
- OH-PEG4-TBA
- HO-PEG4-COOtBu
- t-Butyl 3-Hydroxy(PEG4)propoinate
- CAS:
- 518044-32-1
- MF:
- C15H30O7
- MW:
- 322.39
- Product Categories:
-
- peg
- Mol File:
- 518044-32-1.mol
Hydroxy-PEG4-t-butyl ester Chemical Properties
- Boiling point:
- 406.8±35.0 °C(Predicted)
- Density
- 1.04746 g/mL
- refractive index
- n/D 1.4492
- storage temp.
- 2-8°C
- solubility
- Soluble in Water, DCM
- pka
- 14.36±0.10(Predicted)
- form
- liquid
- color
- Colorless to Light yellow to Light orange
Hydroxy-PEG4-t-butyl ester Usage And Synthesis
Description
Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
reaction suitability
reagent type: cross-linking reagent
Hydroxy-PEG4-t-butyl esterSupplier
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