Basic information Safety Supplier Related

Hydroxy-PEG4-t-butyl ester

Basic information Safety Supplier Related

Hydroxy-PEG4-t-butyl ester Basic information

Product Name:
Hydroxy-PEG4-t-butyl ester
Synonyms:
  • HO-PEG4-CH2CH2COOTBU
  • Hydroxy-PEG-5-t-butyl ester
  • PEG5-t-butly ester
  • Hydroxy-PEG4-t-butly ester
  • OH-PEG4-CH2CH2COOtBu
  • OH-PEG4-TBA
  • HO-PEG4-COOtBu
  • t-Butyl 3-Hydroxy(PEG4)propoinate
CAS:
518044-32-1
MF:
C15H30O7
MW:
322.39
Product Categories:
  • peg
Mol File:
518044-32-1.mol
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Hydroxy-PEG4-t-butyl ester Chemical Properties

Boiling point:
406.8±35.0 °C(Predicted)
Density 
1.04746 g/mL
refractive index 
n/D 1.4492
storage temp. 
2-8°C
solubility 
Soluble in Water, DCM
pka
14.36±0.10(Predicted)
form 
liquid
color 
Colorless to Light yellow to Light orange
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Safety Information

HS Code 
2918999090
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Hydroxy-PEG4-t-butyl ester Usage And Synthesis

Description

Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

reaction suitability

reagent type: cross-linking reagent

Hydroxy-PEG4-t-butyl esterSupplier

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