Methiocarb-d3 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml

Safety Information

Hazard Codes 

T,N

Risk Statements 

25-50/53

Safety Statements 

45-60-61

RIDADR 

UN2811 - class 6.1 - PG 2 - MP - RQ - Toxic solids, organic, n.o.s. HI: all

WGK Germany 

3

Methiocarb-d3 Usage And Synthesis

Description

Methiocarb-d₃ is intended for use as an internal standard for the quantification of methiocarb by GC- or LC-MS. Methiocarb is a carbamate pesticide with insecticidal, molluscicidal, acaricidal, and bird repellant properties. It inhibits acetylcholinesterase (AChE) activity and is toxic to the western flower thrip (F. occidentalis; IC₅₀ = 2.1 μM; LC₅₀ = 3.26 ppm). Methiocarb is also toxic to the land snail M. obstructa (LD₅₀ = 27.4 μg/snail) and the citrus mite A. pelekassi, inducing 94% mortality when used at a concentration of 0.5 ppm. It reduces the seasonal percentages of cotton bolls infested with pink bollworm (P. gossypiella) to 4%, compared with 65% infestation in untreated controls, when applied to cotton fields at a concentration of 1.86 lb/acre. Methiocarb reduces damage to grapes by song birds when applied to vineyards at a concentration of 2.5 lbs AI per 100 gal water per acre. It is an estrogen receptor α (ERα) and ERβ agonist (EC₂₀s = 19.87 and 20.24 μM, respectively) and an androgen receptor antagonist (IC₅₀ = 13.89 μM) in cell-based reporter assays. It is toxic to juvenile rainbow trout (O. mykiss) and guppies (P. reticulata) with LC₅₀ values of 0.8 and 1.48 mg/L, respectively, at 48 hours of exposure. Formulations containing methiocarb have been used in the agricultural control of pests.

Uses

Isotope labelled Methiocarb acts as a pesticide which is used in the protection of crops from insects and fungus.

References

[1] JENSEN S E. Acetylcholinesterase Activity Associated with Methiocarb Resistance in a Strain of Western Flower Thrips,Frankliniella occidentalis(Pergande)[J]. Pesticide Biochemistry and Physiology, 1998, 61 3: Pages 191-200. DOI: 10.1006/pest.1998.2359
[2] H. HUSSEIN. Molluscicidal activity of Pergularia tomentosa (L.), methomyl and methiocarb, against land snails[J]. International Journal of Pest Management, 1999, 45 1: 211-213. DOI: 10.1080/096708799227815
[3] P. NORMAN C C D K Reed. Pesticides Screened Against Two Rust Mites of Citrus[J]. Journal of Economic Entomology, 1967, 63 1: 1409-1412. DOI: 10.1093/jee/63.5.1409
[4] SATOKO TANGE . In vitro metabolism of methiocarb and carbaryl in rats, and its effect on their estrogenic and antiandrogenic activities[J]. Environmental toxicology and pharmacology, 2016, 41: Pages 289-297. DOI: 10.1016/j.etap.2015.08.014
[5] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

Methiocarb-d3(1581694-94-1)Related Product Information

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