L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol bitartrate Chemical Properties

Melting point:

102-105 °C

alpha 

-46 º (c=0.5, HCl)

storage temp. 

2-8°C

solubility 

H₂O: 50 mg/mL, clear

CAS DataBase Reference

69815-49-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

26/27/28

Safety Statements 

45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

F 

8-10-23

MSDS

• Language:English Provider:SigmaAldrich

L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol bitartrate Usage And Synthesis

Uses

adrenergic agonist, antihypotensive

Uses

L-(ndash)-Norepinephrine-(+)-bitartrate is a α,β-adrenoceptor (AR) agonist.

brand name

Levophed (Hospira).

Purification Methods

Recrystallise adrenor from EtOH and store it in the dark under N2. [pKa, Lewis Brit J Pharmacol Chemother 9 488 1954, UV: Bergstr.m et al. Acta Physiol Scand 20 101 1950, Fluorescence: Bowman et al. Science NY 122 32 1955, Tullar J Am Chem Soc 70 2067 1948.] The L-tartrate salt monohydrate has m 102-104.5o, [] D -11o (c 1.6, H2O), after recrystallisation from H2O or EtOH. [Beilstein 13 III 2382.]

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