4-MERCAPTOPHENYLACETIC ACID Chemical Properties

Melting point:

105-109 °C (lit.)

Boiling point:

336.0±17.0 °C(Predicted)

Density 

1.299±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Acetonitrile (Slightly), DMSO (Slightly)

pka

4.21±0.10(Predicted)

form 

Solid

color 

Off-White

Water Solubility 

Slightly soluble in water. Soluble in Dichloromethane, Ethanol and Methanol

Sensitive 

Air Sensitive

Safety Information

Hazard Codes 

Xi

Risk Statements 

37/38-41

Safety Statements 

26-36/37/39

RIDADR 

UN 3335

WGK Germany 

3

HS Code 

2930909899

MSDS

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4-MERCAPTOPHENYLACETIC ACID Usage And Synthesis

Chemical Properties

4-MERCAPTOPHENYLACETIC ACID is White Powder

Uses

4-MERCAPTOPHENYLACETIC ACID is a redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents.

Uses

4-Mercaptophenylacetic acid has been used in the preparation of small ubiquitin-like modifier peptides from bis(2-sulfanylethyl)amido peptide via sequential native chemical ligation.
It can be used:

• On-resin preparation of peptide-^α thiophenylesters which are used in a chemical ligation process for the chemical synthesis of peptides.
• In one pot deprotection of (acetamido-methyl)cysteine following native chemical ligation and/or desulfurization method for the preparation of peptides.
• Palladium facilitated deprotection of N-terminal cysteine through native chemical ligation method for the preparation of synthetically challenging proteins.

4-MERCAPTOPHENYLACETIC ACID(39161-84-7)Related Product Information

• metiazinic acid
• (R)-4-METHYLTHIOMANDELIC ACID
• 4-MERCAPTOPHENYLACETIC ACID
• 4-(TRIFLUOROMETHYLTHIO)PHENYLACETIC ACID
• protizinic acid
• Zaltoprofen
• 4-Methylsulphonylphenylacetic acid
• 4-Methylthiophenylacetic acid
• ETHYL 4-THIOMETHYLBENZOYLFORMATE
• (+/-)-ALPHA-METHYL-(4-SULFONOPHENYL)GLYCINE
• AMINO[4-(METHYLSULFANYL)PHENYL]ACETIC ACID
• 3-MERCAPTOPHENYLACETIC ACID
• 2-MERCAPTOPHENYLACETIC ACID
• Mercaptophenylacetic acid
• 3-MERCAPTOPHENYLACETIC ACID:90%
• [R,(-)]-α-Mercaptophenylacetic acid methyl ester
• [S,(+)]-α-Mercaptophenylacetic acid methyl ester
• [4-(BENZYLSULFONYL)PHENYL]ACETIC ACID