N,N-Diethylacetoacetamide Chemical Properties

Melting point:

-73 °C

Boiling point:

76 °C(lit.)

Density 

0.994 g/mL at 20 °C (lit.)

vapor pressure 

1.387Pa at 25℃

refractive index 

n20/D 1.471

Flash point:

94 °C

storage temp. 

Inert atmosphere,Room Temperature

pka

12.97±0.46(Predicted)

form 

clear liquid

color 

yellow

PH

5-7 (10g/l, H2O, 20℃)

explosive limit

1%(V)

Water Solubility 

10g/L at 26℃

BRN 

636486

LogP

0.41

CAS DataBase Reference

2235-46-3(CAS DataBase Reference)

NIST Chemistry Reference

Butanamide, N,N-diethyl-3-oxo-(2235-46-3)

EPA Substance Registry System

Butanamide, N,N-diethyl-3-oxo- (2235-46-3)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

RTECS 

AK4025000

TSCA 

Yes

HS Code 

29241990

Hazardous Substances Data

2235-46-3(Hazardous Substances Data)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N,N-Diethylacetoacetamide Usage And Synthesis

Chemical Properties

Clear yellow liquid

Uses

N,N-Diethylacetoacetamide is used as intermediate for the manufacture of insecticides, e.g. phosphamidon Product Data Sheet

Uses

N,N-Diethylacetoacetamide is an intermediate in the synthesis of Phosphamidon (E/Z mixture) (P353730), an organophosphate insecticide that acts as a cholinesterase inhibitor.

Uses

N,N-Diethylacetoacetamide is a β-dicarbonyl compound that ?can be used to synthesize potent calcium channel blockers such as 2,6,6-trimethyl-3-diethylaminocarbonyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives and N,N-diethyl-2,6,6-trimethyl-4-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide. It can also undergo Michael addition in the presence of bis(2,4-pentanedionato)nickel(II) catalyst.

Flammability and Explosibility

Flammable

N,N-Diethylacetoacetamide(2235-46-3)Related Product Information

• Ethopabate
• Acetoacetamide
• Diethyl malonate
• Diethyl phthalate
• DIACETAMIDE
• N,N-Dimethylacetamide
• Thioacetamide
• Acetamide
• Celiprolol
• Diethyl ether
• N-ACETOACETYLMORPHOLINE
• a,a-Dichloro-N,N-Diethylacetylacetamide
• Diethylamine
• Diethylacetamide
• Butyramide
• 3-[(4-CHLOROANILINO)METHYLENE]-1,6,7,11B-TETRAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE-2,4(3H)-DIONE
• N,N-HEXAMETHYLENEACETOACETAMIDE
• 2-CHLORO-N,N-DIETHYLACETOACETAMIDE