5-Fluoro-2-methylindole Chemical Properties

Melting point:

98-101 °C (lit.)

Boiling point:

112-120C

Density 

1.219±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Solid

pka

16.73±0.30(Predicted)

color 

Light yellow to Brown

InChI

InChI=1S/C9H8FN/c1-6-4-7-5-8(10)2-3-9(7)11-6/h2-5,11H,1H3

InChIKey

JJIUISYYTFDATN-UHFFFAOYSA-N

SMILES

N1C2=C(C=C(F)C=C2)C=C1C

CAS DataBase Reference

399-72-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-25

Safety Statements 

26-36-45-36/37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

2933998090

MSDS

• Language:English Provider:SigmaAldrich

5-Fluoro-2-methylindole Usage And Synthesis

Description

5-Fluoro-2-methylindole is a chemical intermediate that can be used in the synthesis of other compounds. It is a versatile building block with many applications, such as being a useful intermediate for the synthesis of heterocyclic compounds. This compound reacts with aniline to form 2,6-diaminopyridine, which has been shown to have anti-inflammatory properties.

General Description

5-Fluoro-2-methylindole (5-Fluoro-2-methyl-1H-indole) is a 5-substituted-2-methyl-1H-indole.

Synthesis

1-(5-fluoro-2-nitrophenyl) propane-2-one (0.5mmol, 99 mg), zinc powder (3.0mmol, 196 mg), and acetic acid (6.0mmol, 360 mg) was added to the reaction tube, followed by adding ethanol to 2 ml at 90 °C for 3h. After cooling to room temperature, the reaction system was added 20 ml water. 5-Fluoro-2-methylindole was obtained after purification. 

Solubility in water

Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform, Practically insoluble in water.

5-Fluoro-2-methylindole(399-72-4)Related Product Information

• 2-Methylindole
• Indole
• Bensulfuron methyl
• Thiophanate-methyl
• 3-Methylindole
• Kresoxim-methyl
• Methyl
• Carvotroline
• 5,6-DIFLUOROINDOLE-2-CARBOXYLIC ACID
• ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE
• Gevotroline
• 5,7-Difluoroindole-2-carboxylic acid
• Fluorine
• 5-Fluoro-2,3-dimethyl-1H-indole
• Flucindole
• 5-Fluoroindole-2-carboxylic acid
• 5-FLUORO-3-METHYLINDOLE
• 4-FLUORO-2-METHYLINDOLE