1-(2-METHOXYPHENYL)ETHANOL Chemical Properties

Melting point:

37 °C

Boiling point:

133-135 °C/10 mmHg (lit.)

Density 

1.076 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.54(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

clear liquid

pka

14.89±0.10(Predicted)

color 

Colorless to Light yellow

InChI

InChI=1S/C9H12O2/c1-11-9-5-3-2-4-8(9)6-7-10/h2-5,10H,6-7H2,1H3

InChIKey

XLDRDNQLEMMNNH-UHFFFAOYSA-N

SMILES

C1(CCO)=CC=CC=C1OC

LogP

1.557 (est)

CAS DataBase Reference

7417-18-7(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29094990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

1-(2-METHOXYPHENYL)ETHANOL Usage And Synthesis

Uses

2-Methoxyphenethyl alcohol may be used in chemical synthesis.

Synthesis

Step A: To a stirred suspension of 2-(2-hydroxyethyl)phenol (5 g, 36.2 mmol) and cesium carbonate (Cs2CO3, 38.9 g, 108.7 mmol) in acetone (100 mL) was slowly added iodomethane (6.2 g, 43.4 mmol) under ice-bath conditions. The reaction mixture was stirred continuously at 0 °C for 50 min. Upon completion of the reaction, the mixture was filtered to remove insoluble salts and the filtrate was concentrated under reduced pressure by rotary evaporator. The concentrated crude product was subjected to liquid-liquid extraction with ethyl acetate (EtOAc) and water. The organic layer was separated and dried with anhydrous sodium sulfate (Na2SO4), and the dried organic layer was concentrated by filtration to give 2-(2-methoxyphenyl)ethanol (4.5 g, 29.6 mmol, 82% yield) as a yellow solid.

References

[1] Patent: WO2015/142903, 2015, A2. Location in patent: Page/Page column 96
[2] Patent: WO2015/140133, 2015, A1. Location in patent: Page/Page column 108
[3] Patent: WO2003/103653, 2003, A1. Location in patent: Page 184-185

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