2-Bromo-5-fluorobenzonitrile Chemical Properties

Melting point:

92-95 °C(lit.)

Boiling point:

251.2±25.0 °C(Predicted)

Density 

1.69±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in methanol.

form 

powder to crystal

color 

White to Yellow to Orange

BRN 

8678330

InChIKey

MDHNVHCZDCSTMS-UHFFFAOYSA-N

CAS DataBase Reference

57381-39-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T,Xi

Risk Statements 

20/21/22

Safety Statements 

26-36

RIDADR 

3439

WGK Germany 

3

Hazard Note 

Toxic

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269090

MSDS

• Language:English Provider:2-Bromo-5-fluorobenzonitrile
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Bromo-5-fluorobenzonitrile Usage And Synthesis

Chemical Properties

Colorless solid

Uses

2-Bromo-5-fluorobenzonitrile may be used in the preparation of 5-chloro-4,2?-difluorobiphenyl-2-carbonitrile.

Uses

2-Bromo-5-fluorobenzonitrile is used in the synthesis of pyrimidine functional compounds acting as GABAAα2/α3 binding site agonists used in the treatment of anxiety disorders.

General Description

2-Bromo-5-fluorobenzonitrile can be prepared from 3-fluorobenzonitrile vial bromination using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH).. It undergoes palladium-catalyzed Suzuki coupling with boronic acid derivative to form corresponding biaryl.

2-Bromo-5-fluorobenzonitrile(57381-39-2)Related Product Information

• 4-Bromofluorobenzene
• Ethyl bromodifluoroacetate
• Benzyl bromide
• 2-Bromo-5-fluorophenol
• Fipronil
• 4-Fluorobenzyl chloride
• alpha-Chloro-o-fluorotoluene
• BRETYLIUM TOSYLATE
• Chlorfenapyr
• 2-Fluorobenzonitrile
• p-Tolunitrile
• Florfenicol
• 2-Cyanophenol
• 4-Nitrobenzonitrile
• Benzonitrile
• 1,2-Difluorobenzene
• Transfluthrin
• 4-Fluorobenzonitrile