t-BuBrettPhos Palladacycle Gen. 3 CAS#: 1536473-72-9

t-BuBrettPhos Palladacycle Gen. 3 Basic information

Product Name:

t-BuBrettPhos Palladacycle Gen. 3

Synonyms:

Methanesulfonato 2-Di-t-butylphosphino-3,6-dimethoxy-2'-4' -6'-tri-i-propyl-1,1'-bipheny)(2'-amino-1,1'-biphenyl-2-yl)palladium(II)
Methanesulfonato(2-(di-t-butylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II), min. 98%
METHANESULFONATO(2-(DI-T-BUTYLPHOSPHINO)-3,6-DIMETHOXY-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL)(2'-AMINO-1,1'-BIPHENYL-2-YL)PALLADIUM(II),DICHLOROMETHANEADDUCT,MIN.98%[T-BUBRETTPHOSPALLADACYCLEGEN.3]
t-BuBrettPhos Palladacycle Gen. 3
Methanesulfonato(2-(di-t-butylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II),[t-BuBrettPhos Palladacycle Gen. 3]
Methanesulfonato(2-(di-t-butylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II), dichloromethane adduct, min. 98%[t-BuBrettPhos Palladacycle Gen.
Methanesulfonato[2-(di-t-butylphosphino)-3,6-dimethoxy-2’,4’,6’-tri-i-propyl-1,1’-biphenyl](2’-amino-1,1’-biphenyl-2-yl)palladium(II)
[2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[3,6-dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]bis(1,1-dimethyle

CAS:

1536473-72-9

MF:

C44H63NO5PPdS-

MW:

855.433481

Product Categories:

Buchwald Ligands&Precatalysts
Buchwald Precatalysts Series
Pd

Mol File:

1536473-72-9.mol

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t-BuBrettPhos Palladacycle Gen. 3 Chemical Properties

Melting point:: 119-131°C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
color: brown-green
InChI: InChI=1S/C31H49O2P.C12H10N.CH4O3S.Pd/c1-19(2)22-17-23(20(3)4)27(24(18-22)21(5)6)28-25(32-13)15-16-26(33-14)29(28)34(30(7,8)9)31(10,11)12;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-5(2,3)4;/h15-21H,1-14H3;1-6,8-9H,13H2;1H3,(H,2,3,4);/q;-1;;
InChIKey: VKLHIPFGYVFUGT-UHFFFAOYSA-N
SMILES: [Pd].S(C([H])([H])[H])(=O)(=O)O[H].P(C1=C(C([H])=C([H])C(=C1C1C(=C([H])C(C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C=1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])OC([H])([H])[H])OC([H])([H])[H])(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H].N([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=[C-]1
CAS DataBase Reference: 1536473-72-9

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Safety Information

WGK Germany: 3

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t-BuBrettPhos Palladacycle Gen. 3 Usage And Synthesis

Reaction

Palladium catalyst used for the arylation of primary amides.
Palladium catalyst used for the synthesis of N-aryl carbamates.
Palladium catalyst used for the N-monoarylation of amidines.
Palladium catalyst used for the cross-coupling of aryl chlorides and triflates with sodium cyanate – a practical synthesis of unsymmetrical ureas.
Palladium catalyst used in the synthesis of imidazo[4,5-b]pyridines and imidazo[4,5]pyrazines through amidation of 2-chloro-3-amino-heterocycles.
Palladium catalyst used in the N-arylation of 2-aminothiazoles
Palladium catalyst used in the synthesis of diarylethers under mild conditions.
Palladium catalyst used in the hydroxylation of aryl and heteroaryl halides.

Uses

tBuBrettPhos Pd G3 has been used as a precatalyst for the N-arylation of amino acid esters with aryl triflates under mild reaction conditions and minimal racemization of the amino acid ester. It may also be used to catalyze the conversion of aryl halides to phenols in the presence of benzaldoxime as a hydroxide surrogate.

General Description

tBuBrettPhos Pd G3 is a third generation (G3) Buchwald precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. It is air-, moisture-, and thermally-stable and is highly soluble in a wide range of common organic solvents. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

t-BuBrettPhos Palladacycle Gen. 3Supplier

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Email: sales@kingorgchem.com

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