Basic information Safety Supplier Related

4'-Hydroxy-2,4-dimethoxychalcone

Basic information Safety Supplier Related

4'-Hydroxy-2,4-dimethoxychalcone Basic information

Product Name:
4'-Hydroxy-2,4-dimethoxychalcone
Synonyms:
  • 4'-Hydroxy-2,4-dimethoxychalcone
  • 2-Propen-1-one, 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
  • 4-O-Methylechinatin
  • (E)-3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
  • (2E)-3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
  • 4''-Hydroxy-2,4-dimethoxychalcone
  • 4''-Hydroxy-2,4-dimethoxychalcone, 10 mM in DMSO
  • 4'-Hydroxy-2,dimethoxychalcone
CAS:
151135-64-7
MF:
C17H16O4
MW:
284.31
Mol File:
151135-64-7.mol
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4'-Hydroxy-2,4-dimethoxychalcone Chemical Properties

form 
Solid
color 
Light yellow to yellow
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4'-Hydroxy-2,4-dimethoxychalcone Usage And Synthesis

Uses

4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity[1][2].

in vivo

4'-Hydroxy-2,4-dimethoxychalcone (compound 2; oral; 160 mg/kg) has a T1/2 of 1.94 hours, a Cmax of 158 ng/mL and an AUC of 384 ng?h/mL in four- to five-week-old ICR mice[1].

IC 50

Plasmodium

References

[1] Clare E Gutteridge, et al. In vitro biotransformation, in vivo efficacy and pharmacokinetics of antimalarial chalcones. Pharmacology. 2011;87(1-2):96-104. DOI:10.1159/000322532
[2] Qing-An Zheng, et al. Flavonoids from the Resin of Dracaena cochinchinensis. Helvetica Chimica Acta, 87(5), 1167–1171.

4'-Hydroxy-2,4-dimethoxychalconeSupplier

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