Amino-PEG5-alcohol Chemical Properties

Boiling point:

346.3±32.0 °C(Predicted)

Density 

1.077±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, protect from light

solubility 

Soluble in Water, DMSO, DMF, DCM

pka

14.36±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C10H23NO5/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h12H,1-11H2

InChIKey

DEOUHEFHTMMUCM-UHFFFAOYSA-N

SMILES

C(O)COCCOCCOCCOCCN

Safety Information

HS Code 

2918999090

Amino-PEG5-alcohol Usage And Synthesis

Uses

Amino-PEG5-alcohol is a useful research chemical.

Description

Amino-PEG5-alcohol is an aqueousr soluble PEG linker with one amine and one hydroxyl group. The amine group is reactive with carboxylic acids, activated NHS esters etc. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC 50

PEGs; Non-cleavable Linker

References

[1] Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.
[2] Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.

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