Bromo-PEG2-phosphonic acid ethyl ester Chemical Properties

Boiling point:

387.4±27.0 °C(Predicted)

Density 

1.299±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

color 

Colorless to light yellow

Bromo-PEG2-phosphonic acid ethyl ester Usage And Synthesis

Description

Bromo-PEG2-phosphonic acid diethyl ester is a PEG linker containing a bromine group and a phosphonic acid diethyl ester. The bromine group is a good leaving group and participates in substitution reactions. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.

Uses

Bromo-PEG2-phosphonic acid diethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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