Cbz-N-amido-PEG8-acid Chemical Properties

Boiling point:

681.2±55.0 °C(Predicted)

Density 

1.165±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

4.28±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

Cbz-N-amido-PEG8-acid Usage And Synthesis

Description

Cbz-N-amido-PEG8-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions.

Uses

Cbz-NH-PEG8-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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