Fluorescein-PEG3-Amine
Fluorescein-PEG3-Amine Basic information
- Product Name:
- Fluorescein-PEG3-Amine
- Synonyms:
-
- 5-FITC-PEG3-Amine
- Fluorescein-PEG3-NH2
- Fluorescein-PEG3-Amine
- 5,8,11-Trioxa-2-azatridecanethioamide, 13-amino-N-(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)-
- 1-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-3-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)thiourea
- 1-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-3-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)thiourea
- CAS:
- 1807539-04-3
- MF:
- C29H31N3O8S
- MW:
- 581.64
- Mol File:
- 1807539-04-3.mol
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Fluorescein-PEG3-Amine Chemical Properties
- Boiling point:
- 807.4±75.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DMF, DCM
- pka
- 9.33±0.20(Predicted)
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Fluorescein-PEG3-Amine Usage And Synthesis
Description
Fluorescein-PEG3-Amine is a fluorescein dye with excitation/emmission maximum 494/517 nm containing a free amine group, which can be reactive with cabroxylic acid, activated NHS ester, carbonyl (ketone, aldehyde) etc. The hydophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding.
Uses
Fluorescein-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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Fluorescein-PEG3-Amine(1807539-04-3)Related Product Information
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