Lipoamido-PEG3-Azide Chemical Properties

solubility 

Soluble in DMSO, DMF, DCM

Lipoamido-PEG3-Azide Usage And Synthesis

Description

Lipoamido-PEG3-azide is a PEG linker comprised of a lipoamide group and a terminal azide group. The azide group can participate in copper-catalyzed Click Chemistry reactions with alkynes, DCBO and BCN reagents to form triazole moieties. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Uses

Lipoamido-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Lipoamido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] H. Tetsuo Uyeda, et al. Synthesis of surface ligands to prepare hydrophilic and biologically compatible quantum dots. doi: 10.1117/12.590494

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