ChemicalBook > Product Catalog > Organic Chemistry > Carboxylic acids and derivatives > Carboxylic acid esters and derivatives > Mal-Amido-PEG4-t-butyl ester
Mal-Amido-PEG4-t-butyl ester
Mal-Amido-PEG4-t-butyl ester Basic information
- Product Name:
- Mal-Amido-PEG4-t-butyl ester
- Synonyms:
-
- Mal-Amido-PEG4-t-butyl ester
- MAL-NH-PEG4-CH2CH2COOTBU
- Mal-NH-PEG4-OtBu
- Mal-Amido-PEG4-Boc
- 4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, 1,1-dimethylethyl ester
- Maleimide-C2-Amido-PEG4-Carboxylic Acid tert-Butyl Ester
- N-(18,18-Dimethyl-15-oxo-3,6,9,12,17-pentaoxanonadec-1-yl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide
- tert-butyl 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
- CAS:
- 1415800-35-9
- MF:
- C22H36N2O9
- MW:
- 472.53
- Product Categories:
-
- peg
- Mol File:
- 1415800-35-9.mol
More
Less
Mal-Amido-PEG4-t-butyl ester Chemical Properties
- solubility
- DMSO : 200 mg/mL (423.25 mM; Need ultrasonic)
- form
- clear liquid
- color
- Colorless to Light yellow
More
Less
Mal-Amido-PEG4-t-butyl ester Usage And Synthesis
Description
Mal-Amido-PEG4-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Uses
Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Mal-Amido-PEG4-t-butyl esterSupplier
TOKYO CHEMICAL INDUSTRY CO., LTD.
- Tel
- 03-36680489
- Sales-JP@TCIchemicals.com
TCI Europe
- Tel
- 320-37350700
- sales@tcieurope.eu
TCI AMERICA
- Tel
- 800-4238616
- sales@tciamerica.com
Bide Pharmatech Ltd.
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com
Hunan HuaTeng Pharmaceutical Co., Ltd.,
- Tel
- 400-8592883
- sales@huatengsci.com