Methyltetrazine-PEG5-Alkyne Chemical Properties

Boiling point:

568.5±60.0 °C(Predicted)

Density 

1.176±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, stored under nitrogen

solubility 

Soluble in DMSO, DCM, DMF

pka

1.67±0.10(Predicted)

form 

Solid

color 

Pink to red

Methyltetrazine-PEG5-Alkyne Usage And Synthesis

Description

Methyltetrazine-PEG5-alkyne is a click chemistry bifunctional molecule containing an alkyne group and a hydrophilic PEG spacer which increases water-solubility. This reagent enables simple and efficient incorporation of a tetrazine moiety onto TCO-attached antibodies, peptide or other biomolecule The alkynes can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages.

Uses

Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Methyltetrazine-PEG5-Alkyne(1802907-97-6)Related Product Information

• Methyltetrazine-PEG4-Acid
• Methylamino-PEG3-azide
• FAM alkyne, 6-isomer
• Pyrene -PEG5-propargyl
• APN-C3-PEG4-alkyne
• BDP FL-PEG5-propargyl
• TAMRA alkyne, 6-isomer
• FAM alkyne, 5-isomer
• Methyltetrazine-PEG4-Azide
• Desthiobiotin-PEG4-Alkyne
• Tetrazine-PEG4-maleimide
• Methyltetrazine-PEG4-Amine
• Dde Biotin-PEG4-Alkyne
• Dde Biotin-PEG4-Azide
• Bis-sulfone-PEG3-Azide
• Methyltetrazine-PEG4-NHS Ester