Propargyl-PEG4-bromide Chemical Properties

Boiling point:

334.3±32.0 °C(Predicted)

Density 

1.269±0.06 g/cm3(Predicted)

form 

Liquid

color 

Light yellow to yellow

Propargyl-PEG4-bromide Usage And Synthesis

Description

Propargyl-PEG4-bromide is a crosslinker that can be used in copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage with azides. The bromide (Br) acts as a good leaving group for nucleophilic substitution reactions.

Uses

Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG4-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Non-cleavable Linker; PEGs

References

[1] Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2.

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