t-Boc-Aminoxy-PEG3-alcohol Chemical Properties

Density 

1.109±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

14.36±0.10(Predicted)

t-Boc-Aminoxy-PEG3-alcohol Usage And Synthesis

Description

t-Boc-Aminooxy-PEG3-alcohol is a PEG3 derivative containing a hydroxyl group and Boc-protected amino group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free aminooxy for further reaction.

Uses

t-Boc-Aminooxy-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

t-Boc-Aminoxy-PEG3-alcohol(252378-66-8)Related Product Information

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