DIHYDROMETHYSTICIN
DIHYDROMETHYSTICIN Basic information
- Product Name:
- DIHYDROMETHYSTICIN
- Synonyms:
-
- 6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-2h-pyran-2-on(s)
- 6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)phenethyl)-(s)-2h-pyran-2-on
- 7,8-dihydromethysticin
- dhm
- DIHYDROMETHYLSTICIN
- 7,8-DIHYDROMETHYLSTICIN
- 5,6-Dihydro-4-methoxy-6-[2-(1,3-benzodioxol-5-yl)ethyl]-2H-pyran-2-one
- 6-[2-(1,3-Benzodioxol-5-yl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
- CAS:
- 19902-91-1
- MF:
- C15H16O5
- MW:
- 276.28
- Product Categories:
-
- Coumarins
- Mol File:
- 19902-91-1.mol
DIHYDROMETHYSTICIN Chemical Properties
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly)
- Boiling point:
- 476.1±45.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- Melting point:
- 117-118 °C
- color
- White to Off-White
- BRN
- 91699
- Stability:
- Hygroscopic
- InChIKey
- RSIWXFIBHXYNFM-NSHDSACASA-N
- LogP
- 1.810 (est)
DIHYDROMETHYSTICIN Usage And Synthesis
Description
Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.
Uses
(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one, is used in toxicity studies through in vitro analysis. This complex is found in the roots of kava plant.
Definition
ChEBI: Dihydromethysticin is a member of 2-pyranones and an aromatic ether.
DIHYDROMETHYSTICINSupplier
- Tel
- 021-51320588
- tauto@tautobiotech.com
- Tel
- 021-20908456
- sales@BioChemBest.com
- Tel
- +86-028-82633397 18982077548
- cwb1@biopurify.cn
- Tel
- 028-83311324 1278112614
- climaxbiotech@gmail.com
- Tel
- 021-58958002 18930822973
- SALES@UHNSHANGHAI.COM
DIHYDROMETHYSTICIN(19902-91-1)Related Product Information
- DIHYDROKAVAIN
- YANGONIN
- FLAVOKAWAINC
- FLAVOKAVAIN A(P)
- L-KAWAIN
- Kavain
- METHYSTICIN
- DIHYDROMETHYSTICIN
- DIHYDROMETHYSTICIN(P)
- Dihydrokawain
- DIHYDROMETHYSTICIN
- 5,6-DIHYDRO-2H-PYRAN-2-ONE
- 5,6-DIHYDRO-4-METHOXY-2H-PYRAN
- 3-BENZO[1,3]DIOXOL-5-YL-PROPAN-1-OL
- 1-PHENYL-HEX-5-EN-3-OL
- 5,6-DIHYDRO-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE
- DIHYDROMETHYSTICIN SNAP-N-SHOOT 0.1mg/mL(P)
- PARASORBICACID