2-Pyridinethione Chemical Properties

Melting point:

127-130 °C(lit.)

Boiling point:

184.9±23.0 °C(Predicted)

Density 

1.161 (estimate)

refractive index 

1.5605 (estimate)

Flash point:

125°C

storage temp. 

2-8°C

solubility 

Slightly soluble in chloroform, methanol and dimethyl sulfoxide.

form 

Crystalline Powder

pka

pK1:－1.07(＋1);pK2:10.00(0) (20°C)

color 

Yellow to brownish

Water Solubility 

50 g/L (20 ºC)

Sensitive 

Air Sensitive

BRN 

105758

Stability:

Stable. Incompatible with strong bases, strong oxidizing agents.

InChIKey

WHMDPDGBKYUEMW-UHFFFAOYSA-N

LogP

-0.130

CAS DataBase Reference

2637-34-5(CAS DataBase Reference)

NIST Chemistry Reference

2(1H)-Pyridinethione(2637-34-5)

EPA Substance Registry System

2-Mercaptopyridine (2637-34-5)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-36/38-22

Safety Statements 

26-36-28A-22

WGK Germany 

3

RTECS 

UT9600000

F 

10-23

TSCA 

Yes

HS Code 

29339900

MSDS

• Language:English Provider:2-Mercaptopyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Pyridinethione Usage And Synthesis

Chemical Properties

2-Mercaptopyridine is yellow crystalline powder

Uses

2-Mercaptopyridine Can be used to coat porous media to purify plasmid DNA.

Uses

Employed as a ligand in metal complexes.1,2

Uses

Employed as a ligand in metal complexes. It can be used to coat porous media to purify plasmid DNA.

Definition

ChEBI: Pyridine-2-thiol is pyridine substituted at C-2 by a sulfanyl group. It has a role as a fluorescence quencher and an allergen. It is a member of pyridines and an aryl thiol.

Purification Methods

If impure, dissolve in CHCl3, wash with dilute AcOH, H2O, dry (MgSO4), evaporate under reduced pressure and recrystallise the residue from *C6H6 or H2O. 2-Methylmercaptopyridine (b 100-104o/33mm, pK2 0 3.59) was formed by treatment with MeI/NaOH. [Albert & Barlin J Chem Soc 2394 1959, Phillips & Shapiro J Chem Soc 584 1942, Beilstein 21 H 45, 21 III/IV 373, 21/7 V 147.]

2-Pyridinethione(2637-34-5)Related Product Information

• 2-Chloro-3-cyanopyridine
• Chromium picolinate
• 2,6-Lutidine
• Sulfasalazine
• 2-Mercaptopyridine monoxide,2-MERCAPTOPYRIDINE N-OXIDE,2-MERCAPTOPYRIDINE-1-OXIDE
• 2-(METHYLTHIO)NICOTINYL CHLORIDE
• 2-(ALLYLTHIO)NICOTINIC ACID
• 2-(METHYLTHIO)NICOTINIC ACID
• 2,2'-DITHIOBIS(5-NITROPYRIDINE)
• 6,6'-DITHIODINICOTINIC ACID
• 2-PYRIDINESULFONYLACETONITRILE
• 2,2'-Dithiodipyridine
• 2-(N-PROPYLTHIO)NICOTINIC ACID
• 2-(ETHYLTHIO)NICOTINIC ACID
• 2-(ETHYLTHIO)NICOTINOYL CHLORIDE
• 2-MERCAPTOPYRIDINE-3-CARBOXYLIC ACID
• SPDP
• 2-(PHENYLTHIO)QUINOLINE