Tetrachlorophthalic anhydride Chemical Properties

Melting point:

253-257 °C(lit.)

Boiling point:

371 °C(lit.)

Density 

1.49

vapor pressure 

0.16 mm Hg ( 145 °C)

Flash point:

362°C

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly, Heated), DMSO (Heated), Methanol (Slightly, Heated)

form 

Flakes

pka

3.01[at 20 ℃]

color 

White to off-white

Water Solubility 

0.8 mg/L (21 ºC)

Sensitive 

Moisture Sensitive

BRN 

211560

Exposure limits

ACGIH: TWA 0.002 mg/m3 (Skin)

Stability:

Stable. Reacts with water. Combustible. Incompatible with strong oxidizing agents. Air and moisture sensitive.

InChIKey

AUHHYELHRWCWEZ-UHFFFAOYSA-N

LogP

3.2 at 25℃

CAS DataBase Reference

117-08-8(CAS DataBase Reference)

NIST Chemistry Reference

1,3-Isobenzofurandione, 4,5,6,7-tetrachloro-(117-08-8)

EPA Substance Registry System

Tetrachlorophthalic anhydride (117-08-8)

Safety Information

Hazard Codes 

T,N,Xn

Risk Statements 

45-41-42/43-50/53-48/22

Safety Statements 

53-22-24-26-37/39-45-60-61-36/37/39

RIDADR 

UN 3077 9/PG 3

WGK Germany 

2

RTECS 

TI3450000

F 

10-21

TSCA 

Yes

HazardClass 

9

PackingGroup 

III

HS Code 

29173990

Hazardous Substances Data

117-08-8(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: > 15800 mg/kg LD50 dermal Rabbit > 5000 mg/kg

MSDS

• Language:English Provider:4,5,6,7-Tetrachloro-1,3-isobenzofurandione
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Tetrachlorophthalic anhydride Usage And Synthesis

Chemical Properties

white needle-like crystals or powder

Uses

Intermediate in dyes, pharmaceuticals, plasticizers, and other organic materials; flame-retardant in epoxy resins.

Uses

Tetrachlorophthalic Anhydride is used in the synthesis of nucleoside analogues with a specific structure as apoptosis inducing active compounds. Also used in the synthesis of carbonic anhydrase inhbitors. Chlorinated Reactive Flame Retardant Intermediate

Definition

ChEBI: A cyclic dicarboxylic anhydride that is phthalic anhydride chlorinated at the 4-, 5-, 6- and 7-positions.

General Description

Odorless needle-like crystals or white powder.

Air & Water Reactions

Sensitive to air and moisture.

Reactivity Profile

4,5,6,7-Tetrachloro-1,3-isobenzofurandione reacts exothermically with water. This reaction is expected to be slow, but can become vigorous if local heating accelerates it. Reaction with water is accelerated by acids. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Fire Hazard

Flash point data for 4,5,6,7-Tetrachloro-1,3-isobenzofurandione are not available. 4,5,6,7-Tetrachloro-1,3-isobenzofurandione is probably combustible.

Flammability and Explosibility

Not classified

Purification Methods

Crystallise the anhydride from chloroform or *benzene, then sublime it in a vacuum. [Beilstein 17/11 V 260.]

Tetrachlorophthalic anhydride(117-08-8)Related Product Information

• 3,4-Dichlorobenzoic acid
• 3-CHLORO-O-XYLENE
• 3-Chlorobenzoic acid
• 4-Chloro-1,2-dimethylbenzene
• 4-CHLORO-2-METHYLBENZALDEHYDE
• 7-Chlorophthalide
• 1,4-Dichlorobenzene
• 2,5-Dichlorobenzoic acid
• 4-Chlorobenzaldehyde
• 3,5-Dichlorobenzyl alcohol
• 3,4-Dichlorotoluene
• 2,4,5-Trichlorobenzoic acid
• 2,3,5-Trichlorobenzaldehyde
• 2,4-Dichlorotoluene
• 4-Chlorophthalic anhydride
• 3-Chlorobenzaldehyde
• 3,6-Dichlorophthalic anhydride
• METHYL 4-CHLOROBENZOATE