MPEG12-NH2 Chemical Properties

Boiling point:

583.6±45.0 °C(Predicted)

Density 

1.073±0.06 g/cm3(Predicted)

storage temp. 

-20°C, protect from light, stored under nitrogen

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

8.74±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C25H53NO12/c1-27-4-5-29-8-9-31-12-13-33-16-17-35-20-21-37-24-25-38-23-22-36-19-18-34-15-14-32-11-10-30-7-6-28-3-2-26/h2-26H2,1H3

InChIKey

MSKSQCLPULZWNO-UHFFFAOYSA-N

SMILES

C(N)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC

MPEG12-NH2 Usage And Synthesis

Description

m-PEG12-amine is a monodisperse PEG linker containing an amino group, It is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC 50

PEGs; Non-cleavable Linker

References

[1] Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259. DOI:10.1021/acs.bioconjchem.8b00906
[2] Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1.

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