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Selank peptide

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Selank peptide Basic information

Product Name:
Selank peptide
Synonyms:
  • Selank peptide
  • SelankAcetate
  • PL14736
  • L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline
  • L-THREONYL-L-LYSYL-L-PROLYL-L-ARGINYL-L-PROLYLGLYCYL-L-PROLINE; MONOACETATE
  • H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH
  • SLANK
  • Selank peptid
CAS:
129954-34-3
MF:
C33H57N11O9
MW:
751.87
EINECS:
232-660-2
Product Categories:
  • 129954-34-3
Mol File:
129954-34-3.mol
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Selank peptide Chemical Properties

Melting point:
134-136 °C
Density 
1.53±0.1 g/cm3(Predicted)
pka
3.43±0.20(Predicted)
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
InChI
InChI=1S/C33H57N11O9/c1-19(45)26(35)29(49)41-20(8-2-3-13-34)30(50)44-17-6-11-23(44)28(48)40-21(9-4-14-38-33(36)37)31(51)43-16-5-10-22(43)27(47)39-18-25(46)42-15-7-12-24(42)32(52)53/h19-24,26,45H,2-18,34-35H2,1H3,(H,39,47)(H,40,48)(H,41,49)(H,52,53)(H4,36,37,38)/t19-,20+,21+,22+,23+,24+,26+/m1/s1
InChIKey
JTDTXGMXNXBGBZ-YVHUGQOKSA-N
SMILES
C(O)(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H]([C@H](O)C)N
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Selank peptide Usage And Synthesis

Description

Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine in mice. It also decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.

Uses

Selank peptide has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and antistress drug that relieves aggression and fear reaction in different animal species. It is often prescribed for its anxiolytic properties, immune improvement, gastric protection, and with opioid and alcohol withdrawal/ dependence. It also has a nootropic action, which positively influences the formation of memory and learning processes, and marked immunomodulatory activity.

benefits

Selank peptide has the following benefits: It improves anxiety and stress reactions. Enhances memory and learning. Strengthens immune function by increasing inflammatory proteins to help fight infections. Increases BDNF (brain-derived neurotrophicfactor) - a vital brain-growth compoundrelated to learning and memory. Prevent weight gain and reduce cholesterol. Decreases alcohol-withdrawal-related anxiety. Decreased blood pressure and increased brain blood flow. Helps to increase lymph flow to the stomach and decrease stomach ulcers. Stabilizes blood enkephalins - natural peptides that can reduce stress.

Mechanism of action

It is known that the classical benzodiazepines act via gamma-aminobutyric acid (GABA) type A receptors. They enhance the GABA effect by allosteric modulation, which increases the frequency of opening of channels for chlorine ions. The Selank action mechanism may be related to its ability to affect the performance of the GABAergic system.

Side effects

These are the possible side effects:
Anxiety
Headaches
Nausea
Dizziness
Fatigue

Selank peptideSupplier

Sichuan Taihui Biotechnology Co., Ltd Gold
Tel
028-87189093 18599944286
Email
272503470@qq.com
Chengdu Youngshe Chemical Co., Ltd. Gold
Tel
+86-17380623303 +86-17380623303
Email
Caroline@youngshechem.com
Sichuan Takele Biotechnology Co., Ltd. Gold
Tel
+86-028-64348587 15680781153
Email
sales@takelepeptide.com
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd Gold
Tel
13770887460
Email
wenxi@jszkhy.com
Nanjing Yuanpeptide Biotech Co.,Ltd. Gold
Tel
18168071971
Email
support@yuan-peptide.com
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