THP-PEG4 Chemical Properties

Boiling point:

270 °C

Density 

1.09±0.1 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

pka

14.36±0.10(Predicted)

color 

Colorless to light yellow

Safety Information

HS Code 

2942000090

THP-PEG4 Usage And Synthesis

Description

THP-PEG4 is PEG linker containing a THP protecting group and a terminal hydroxyl. THP is an acid labile, alcohol protecting group. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG chain increases the water solubility of the compound in aqueous environments. The water solubility properties of the PEG linker are enhanced with longer PEG chains.

Uses

THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

THP-PEG4(60221-37-6)Related Product Information

• THP-SS-alcohol
• THP-PEG3
• THP-PEG8-Tos
• TETRAHYDROPYRANYLDIETHYLENEGLYCOL
• THP-SS-PEG1-Tos
• 2-(TETRAHYDRO-2H-PYRAN-2-YLOXY)ETHANOL
• THP-SS-PEG1-t-butyl ester
• THP-PEG6-alcohol
• THP-PEG5
• THP-PEG6
• THP-PEG7-OH