5-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties

Melting point:

>230 °C

Boiling point:

564.3±45.0 °C(Predicted)

Density 

1.794±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

10.60±0.40(Predicted)

form 

Solid

color 

Off-white to gray

InChI

InChI=1S/C13H9BrN2O4/c14-6-1-2-7-8(5-6)13(20)16(12(7)19)9-3-4-10(17)15-11(9)18/h1-2,5,9H,3-4H2,(H,15,17,18)

InChIKey

MWMSBQXTHIEBNT-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C=C(Br)C=C2)C(=O)N1C1CCC(=O)NC1=O

5-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Usage And Synthesis

Description

5-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is a derivative of thalidomide with an bromide atom on the benzyl ring

Chemical Properties

White to Light gray to Light yellow powder to crystal

Uses

Thalidomide-5-Br (compound 4) is a compound with a bromodomain. Thalidomide-5-Br can be used in the research of inflammation, tumor and neurology[1].

References

[1] Yeung, et al. "Novel thalidomide analogues with potent NFκB and TNF expression inhibition." MedChemComm 2.11 (2011): 1073-1078.