Basic information Safety Supplier Related

ML 18

Basic information Safety Supplier Related

ML 18 Basic information

Product Name:
ML 18
Synonyms:
  • BRS-3 antagonist
  • ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4
  • ML18, >98%
  • ML 18
  • (2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
  • (S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide
  • Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18
CAS:
1422269-30-4
MF:
C32H35N5O5
MW:
569.66
Mol File:
1422269-30-4.mol
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ML 18 Chemical Properties

Boiling point:
821.8±65.0 °C(Predicted)
Density 
1.291±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
A solid
pka
11.99±0.46(Predicted)
color 
White to yellow
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ML 18 Usage And Synthesis

Description

ML-18 is a non-peptide bombesin receptor subtype 3 (BB3) antagonist that inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM). It is selective for BB3 over the gastrin releasing peptide receptor (GRPR) and the neuromedin B receptor (NMBR) with IC50 values of 16 and >100 μM, respectively, in a radioligand binding assay. ML-18 (16 μM) reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells. It also inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells.

Uses

ML-18 is a non-peptide bombesin receptor subtype-3 antagonist. It also inhibits lung cancer growth.

ML 18Supplier

Shanghai JiYi Biotechnology Co. Ltd.
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13621943973
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Shanghai EFE Biological Technology Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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Beijing Solarbio Science & Tecnology Co., Ltd.
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Medi-tech Bioscientific Co., Ltd.
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0519-83246372 13585352506