ML 18
ML 18 Basic information
- Product Name:
- ML 18
- Synonyms:
-
- BRS-3 antagonist
- ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4
- ML18, >98%
- ML 18
- (2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
- (S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide
- Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18
- CAS:
- 1422269-30-4
- MF:
- C32H35N5O5
- MW:
- 569.66
- Mol File:
- 1422269-30-4.mol
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ML 18 Chemical Properties
- Boiling point:
- 821.8±65.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 11.99±0.46(Predicted)
- color
- White to yellow
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ML 18 Usage And Synthesis
Description
ML-18 is a non-peptide bombesin receptor subtype 3 (BB3) antagonist that inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM). It is selective for BB3 over the gastrin releasing peptide receptor (GRPR) and the neuromedin B receptor (NMBR) with IC50 values of 16 and >100 μM, respectively, in a radioligand binding assay. ML-18 (16 μM) reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells. It also inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells.
Uses
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist. It also inhibits lung cancer growth.
ML 18Supplier
Shanghai JiYi Biotechnology Co. Ltd.
- Tel
- 13621943973
- sales@shjiyipharmatech.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai Chaolan Chemical Technology Center
- Tel
- QQ:65489617 15618227136
- Sales@ATKchemical.com
Beijing Solarbio Science & Tecnology Co., Ltd.
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
Medi-tech Bioscientific Co., Ltd.
- Tel
- 0519-83246372 13585352506
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