2-Pyridinecarbothioamide, N-2-pyridinyl-
2-Pyridinecarbothioamide, N-2-pyridinyl- Basic information
- Product Name:
- 2-Pyridinecarbothioamide, N-2-pyridinyl-
- Synonyms:
-
- 2-Pyridinecarbothioamide, N-2-pyridinyl-
- NSC 185058
- N-(Pyridin-2-yl)pyridine-2-carbothioamide
- Inhibitor,NSC-185058,Atg4,NSC 185058,Autophagy,Autophagy-related 4,inhibit
- CAS:
- 39122-38-8
- MF:
- C11H9N3S
- MW:
- 215.27
- Mol File:
- 39122-38-8.mol
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2-Pyridinecarbothioamide, N-2-pyridinyl- Chemical Properties
- Melting point:
- 82 °C(Solv: ethanol, 70% (64-17-5))
- Boiling point:
- 378.2±40.0 °C(Predicted)
- Density
- 1.323±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2.5 mg/ml
- form
- A crystalline solid
- pka
- 8.76±0.70(Predicted)
- color
- Light yellow to yellow
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2-Pyridinecarbothioamide, N-2-pyridinyl- Usage And Synthesis
Uses
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1].
in vivo
NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1].
References
[1] Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32(6):840-855.e8. DOI:10.1016/j.ccell.2017.11.005
2-Pyridinecarbothioamide, N-2-pyridinyl-Supplier
Sichuan Wei Keqi Biological Technology Co., Ltd.
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- 028-81700200 18116577057
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Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Tianjin Kailiqi Biotechnology Co., Ltd.
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- 15076683720
- klq@cw-bio.com
Beijing Solarbio Science & Tecnology Co., Ltd.
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- 010-50973130 18101056239
- 3193328036@qq.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com
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