4-(Trifluoromethoxy)aniline Chemical Properties

Boiling point:

73-75 °C10 mm Hg(lit.)

Density 

1.32 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.463(lit.)

Flash point:

177 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

pka

3.75±0.10(Predicted)

form 

Liquid

color 

Clear colorless to yellow

Specific Gravity

1.310

BRN 

2090209

Stability:

Hygroscopic

InChI

InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2

InChIKey

XUJFOSLZQITUOI-UHFFFAOYSA-N

SMILES

C1(N)=CC=C(OC(F)(F)F)C=C1

CAS DataBase Reference

461-82-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xi,Xn

Risk Statements 

24/25-33-38-41-36/37/38-20/21/22

Safety Statements 

26-36/37/39-45-36

RIDADR 

UN 2941 6.1/PG 3

WGK Germany 

2

Hazard Note 

Toxic

HazardClass 

IRRITANT, TOXIC

HazardClass 

6.1

PackingGroup 

III

HS Code 

29222900

MSDS

• Language:English Provider:4-(Trifluoromethoxy)aniline
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-(Trifluoromethoxy)aniline Usage And Synthesis

Chemical Properties

CLEAR YELLOW LIQUID

Uses

4-(Trifluoromethoxy)aniline was used in the synthesis of:

• side-group liquid-crystalline polymethacrylates with fluorine-containing mesogens
• derivatives of 3-(quinolin-3-yl)acrylates
• series of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves

Uses

4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole, a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.

4-(Trifluoromethoxy)aniline(461-82-5)Related Product Information

• 4-Methoxyphenylacetone
• 4'-(Trifluoromethoxy)acetophenone
• o-Anisaldehyde
• Anisole
• (Trifluoromethoxy)benzene
• 3-Methoxybenzaldehyde
• 4-(Trifluoromethoxy)chlorobenzene
• 2-(Trifluoromethoxy)aniline
• 4-Aminobenzotrifluoride
• (3-Methoxyphenyl)acetonitrile
• 4-Methoxyphenylacetic acid
• 4-Methoxybenzylchloride
• p-Trifluoromethoxy phenol
• 3-(Trifluoromethoxy)aniline
• Trimethyl phosphite
• 2-Fluoroaniline
• Aniline
• 4-Fluoroaniline