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4-(Trifluoromethoxy)aniline

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4-(Trifluoromethoxy)aniline Basic information

Product Name:
4-(Trifluoromethoxy)aniline
Synonyms:
  • Riluzole Related Compound A (25 mg) (4-trifluoromethoxyaniline)
  • 4-(TrifluoroMethoxy)aniline, 99+% 2.5GR
  • Riluzole Related CoMpound A
  • For trifluoromethoxy aniline
  • 4- threedifluoro Methoxyaniline
  • 4-TrifluoroMethoxyaniline, 97+%
  • The trifluoro Methoxy aniline
  • 4-(TrifluoroMe
CAS:
461-82-5
MF:
C7H6F3NO
MW:
177.12
EINECS:
207-317-5
Product Categories:
  • Building Blocks
  • C7
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
  • Pyridines
  • Trifluoroanisole series
  • Trifluoromethoxybenzene Series
  • Anilines, Aromatic Amines and Nitro Compounds
  • Amines
  • Phenyls & Phenyl-Het
  • Phenyls & Phenyl-Het
  • Pharmaceutical Intermediate
  • amine
  • john's
Mol File:
461-82-5.mol
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4-(Trifluoromethoxy)aniline Chemical Properties

Boiling point:
73-75 °C10 mm Hg(lit.)
Density 
1.32 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.463(lit.)
Flash point:
177 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
3.75±0.10(Predicted)
form 
Liquid
color 
Clear colorless to yellow
Specific Gravity
1.310
BRN 
2090209
Stability:
Hygroscopic
InChI
InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2
InChIKey
XUJFOSLZQITUOI-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference
461-82-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
T,Xi,Xn
Risk Statements 
24/25-33-38-41-36/37/38-20/21/22
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 2941 6.1/PG 3
WGK Germany 
2
Hazard Note 
Toxic
HazardClass 
IRRITANT, TOXIC
HazardClass 
6.1
PackingGroup 
III
HS Code 
29222900

MSDS

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4-(Trifluoromethoxy)aniline Usage And Synthesis

Chemical Properties

CLEAR YELLOW LIQUID

Uses

4-(Trifluoromethoxy)aniline was used in the synthesis of:

  • side-group liquid-crystalline polymethacrylates with fluorine-containing mesogens
  • derivatives of 3-(quinolin-3-yl)acrylates
  • series of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves

Uses

4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole, a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.

4-(Trifluoromethoxy)aniline Preparation Products And Raw materials

Preparation Products

Raw materials

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