4-Methoxybenzylchloride Chemical Properties

Melting point:

−1 °C(lit.)

Boiling point:

117-118 °C14 mm Hg(lit.)

Density 

1.155 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.548(lit.)

Flash point:

229 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Liquid

color 

Clear colorless to pale yellow

Water Solubility 

slowly decomposes

Stability:

Moisture Sensitive

InChIKey

MOHYOXXOKFQHDC-UHFFFAOYSA-N

CAS DataBase Reference

824-94-2(CAS DataBase Reference)

NIST Chemistry Reference

«alpha»-Chloro-4-methoxytoluene(824-94-2)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-27-36/37/39-45

RIDADR 

UN 3265 8/PG 3

WGK Germany 

3

F 

10-19-21

Autoignition Temperature

109℃

Hazard Note 

Corrosive

TSCA 

No

HazardClass 

8

PackingGroup 

III

HS Code 

29093090

MSDS

• Language:English Provider:1-Chloromethyl-4-methoxybenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

4-Methoxybenzylchloride Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

O/N protecting group reagent which can be mildly oxidatively cleaved, e.g., with ceric ammonium nitrate.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 20, p. 190, 1977 DOI: 10.1021/jm00212a002
The Journal of Organic Chemistry, 53, p. 3634, 1988 DOI: 10.1021/jo00250a048

General Description

4-Methoxybenzyl chloride undergoes mild oxidative claevage with ceric ammonium nitrate.

Purification Methods

Purify 4-anisyl chloride by fractional distillation under vacuum, and the middle fraction is redistilled at 10-6 mm at room temperature by intermittent cooling of the receiver in liquid N2, and the middle fraction is collected. [Mohammed & Kosower J Am Chem Soc 93 2709 1971, Beilstein 6 IV 2137.]

4-Methoxybenzylchloride(824-94-2)Related Product Information

• 4-Methoxybenzoyl chloride
• 4-Fluorobenzyl chloride
• Anisole
• 2-Chlorobenzyl chloride
• 1,2-Dichloro-4-(chloromethyl)benzene
• 4-Methoxybenzyl alcohol
• 4-Methoxybenzylamine
• 4-Chlorobenzyl cyanide
• 4-Nitrobenzyl chloroformate
• 4-Chlorobenzyl chloride
• Benzyl chloroformate
• 3-Bromoanisole
• 4-Methylbenzyl chloride
• 4'-Methoxyacetophenone
• 4-Methoxybenzyl cyanide
• Methoxypropiophenone
• 4-Formylbenzoic acid
• 4-Methoxyphenethylamine