Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester Chemical Properties

storage temp. 

-20°C, protect from light, stored under nitrogen

solubility 

Soluble in DMSO, DCM, DMF

form 

Oil

color 

Colorless to light yellow

Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester Usage And Synthesis

Description

DBCO-PEG12-NHS Ester is a monodisperse PEG linker which enable free copper click chemistry with N3 group. NHS ester moiety can react specifically and efficiently with primary amines to form a covalent amide bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation.

Uses

DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester(2093934-94-0)Related Product Information

• DBCO-PEG12-amine
• DBCO-PEG12-acid
• DBCO-PEG12-O-NH2
• Azadibenzocyclooctyne-PEG12-Maleimide