AA-115 (APG-115) CAS#: 1818393-16-6

Product Name:

AA-115 (APG-115)

Synonyms:

AA-115 (APG-115)
APG-115
AA-115
Alrizomadlin
Bicyclo[2.2.2]octane-1-carboxylic acid, 4-[[[(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-1'',2''-dihydro-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-[3H]indol]-5'-yl]carbonyl]amino]-
4-((3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic acid
4-{[(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxo-1'',2''-dihydrodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indol]-5'-yl]amido}bicyclo[2.2.2]octane-1-carboxylic acid
APG-115 (Alrizomadlin)

CAS:

1818393-16-6

MF:

C34H38Cl2FN3O4

MW:

642.59

Mol File:

1818393-16-6.mol

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Boiling point:: 805.8±65.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 4.76±0.10(Predicted)
color: White to off-white
InChIKey: YJCZPJQGFSSFOL-MNZPCBJKSA-N
SMILES: C12(C(O)=O)CCC(NC([C@@H]3N(CC)C4([C@]5(C6=C(NC5=O)C=C(Cl)C=C6)[C@H]3C3=CC=CC(Cl)=C3F)CCCCC4)=O)(CC1)CC2

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APG 115 is used in the treatment and prevention of osteoarthritis.

Alrizomadlin (Delivered orally; 100 mg/kg; once daily; 10 days) enhances radiation antitumor effect in gastric adenocarcinoma in vivo^[3].

Animal Model:	Four-week-old male BALB/c athymic nude mice with MKN45 cells^[3]
Dosage:	100 mg/kg
Administration:	Deliverer orally; once daily; 10 days
Result:	Decreased xenograft tumor growth.

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