25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane Chemical Properties

Boiling point:

462.5±40.0 °C(Predicted)

Density 

1.198±0.06 g/cm3(Predicted)

storage temp. 

-20°C, sealed storage, away from moisture

solubility 

Soluble in Water, DMSO, DMF, DCM

form 

Liquid

color 

Colorless to light yellow

25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane Usage And Synthesis

Description

m-PEG8-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG8-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane(1056881-04-9)Related Product Information

• 1,2-Dimethoxyethane
• 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol
• 3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine
• OCTAETHYLENE GLYCOL MONOMETHYL ETHER
• MPEG8-N3
• m-PEG7-CH2COOH
• MPEG7-CH2CH2COOH
• m-PEG8-Ph-CHO
• m-PEG8-aldehyde
• m-PEG8-NHS ester
• m-PEG5-bromide
• Bromo-PEG3-Acid
• Triethylene Glycol 2-Bromoethyl Methyl Ether
• mPEG12-Br
• mPEG11-Br
• m-PEG6-bromide
• mPEG16-Br
• m-PEG9-bromide