N-DBCO-N-bis(PEG2-acid) Chemical Properties

Boiling point:

891.4±65.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

pka

3.97±0.10(Predicted)

color 

Light yellow to yellow

N-DBCO-N-bis(PEG2-acid) Usage And Synthesis

Description

N-DBCO-N-bis(PEG2-acid) is a branched click chemistry linker containing a DBCO and two PEG2-acid chains attached to a central nitrogen group. The DBCO group participates in copper-free Click Chemistry reactions with azide. Carboxylic acid (CO2H) allows for reactions with primary amine groups using activators such as EDC or HATU to form a stable bond.

Uses

N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-DBCO-N-bis(PEG2-C2-acid) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

N-DBCO-N-bis(PEG2-acid)(2110449-00-6)Related Product Information

• N-DBCO-N-bis(PEG2-NHS ester)