Propargyl-PEG6-NHS ester Chemical Properties

Boiling point:

530.8±60.0 °C(Predicted)

Density 

1.22±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM

Propargyl-PEG6-NHS ester Usage And Synthesis

Description

Propargyl-PEG6-NHS ester is an amine reactive linker. The alkyne in this linker can react with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reaction. The PEG spacer increases solubility of the molecule in aqueous media.

Uses

Propargyl-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG6-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Cleavable Linker; PEGs; Alkyl/ether

References

[1] Anandan Palani, et al. Insulin-incretin conjugates. WO2017160669A1.

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