1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Chemical Properties

Melting point:

218.0 to 223.0 °C

storage temp. 

Store at RT

solubility 

DMSO: soluble2mg/mL (clear solution, warmed)

form 

powder

color 

white to beige

CAS DataBase Reference

1837-91-8(CAS DataBase Reference)

EPA Substance Registry System

Cyclohexane, 1,2,3,4,5,6-hexabromo- (1837-91-8)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-36-22

Safety Statements 

26-36/37/39

WGK Germany 

3

TSCA 

Yes

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Usage And Synthesis

Uses

1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.

Definition

ChEBI: 1,2,3,4,5,6-hexabromocyclohexane is a bromohydrocarbon that is cyclohexane in which the hydrogen at positions 1,2,3,4,5 and 6 have been replaced by bromo groups. It is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a bromohydrocarbon and a bromoalkane. It derives from a hydride of a cyclohexane.

Biological Activity

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M.

storage

Room temperature

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE(1837-91-8)Related Product Information

• 1,2,5,6-TETRABROMOHEXANE
• 1,5-Dibromopentane
• 3,4-DIBROMOHEXANE
• 1,2,3,4-Tetrabromobutane
• 2,4-DIBROMOPENTANE
• 1,2,4-Tribromobutane
• 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
• 1,3-Dibromobutane
• 2,5-Dibromohexane
• TRANS-1,2-DIBROMOCYCLOHEXANE
• 1,2-DIBROMOCYCLOHEXANE
• 1,2-Dibromobutane
• 1,4-Dibromopentane
• 2,3-DIBROMOBUTANE
• Bromocyclohexane
• 1,4-Dibromobutane
• 1,2,3-Tribromopropane
• 1,2-Dibromopentane