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ZORUBICIN HCL

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ZORUBICIN HCL Basic information

Product Name:
ZORUBICIN HCL
Synonyms:
  • ZORUBICIN HCL
  • 22050r.p.
  • benzoicacidhydrazide,3-hydrazonewithdaunorubicin,monohydrochloride
  • daunorubicin,benzoylhydrazone,monohydrochloride
  • nsc-164011
  • rp22,050hydrochloride
  • rubidaz
  • rubidazone,monohydrochloride
CAS:
36508-71-1
MF:
C34H36ClN3O10
MW:
682.12
EINECS:
253-076-4
Mol File:
36508-71-1.mol
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ZORUBICIN HCL Chemical Properties

alpha 
D20 -50° (c = 0.2 in water)
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
Orange to Dark Red
Stability:
Light Sensitive
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Safety Information

Toxicity
LD50 in mice (mg/kg): 13.66 s.c., 4.42 i.p., 8.50 i.v. (Maral, 1972)
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ZORUBICIN HCL Usage And Synthesis

Originator

Zorubicin Hydrochloride,ZYF Pharm Chemical

Uses

Zorubicin Hydrochloride is an anthracycline anti-cancer drug related to Daunorubicin (D194500).

Uses

Antineoplastic.

Manufacturing Process

9.024 g daunorubicin-hydrochloride (its preparation and physicochemical properties have been described in British Patent Specification No 985 598) was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162 g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained precipitate was filtered off, washed with 100 ml of ethanol and dried in vacuum at 20°C. It was dissolved in water and small quantity of insoluble product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6- trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12- trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide dihydrochloride (zorubicin) was obtained as red-orange crystalline powder; [α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form of different non-toxic salts such as benzoates, fumarates, maleates, tartrates and so on. The best among these compounds proves to be daunorubicin benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No. 1,578,722 published in 1967, Class CO7d).

Therapeutic Function

Antineoplastic, Antileukemic

ZORUBICIN HCL Preparation Products And Raw materials

Raw materials

ZORUBICIN HCLSupplier

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