ZORUBICIN HCL
ZORUBICIN HCL Basic information
- Product Name:
- ZORUBICIN HCL
- Synonyms:
-
- ZORUBICIN HCL
- 22050r.p.
- benzoicacidhydrazide,3-hydrazonewithdaunorubicin,monohydrochloride
- daunorubicin,benzoylhydrazone,monohydrochloride
- nsc-164011
- rp22,050hydrochloride
- rubidaz
- rubidazone,monohydrochloride
- CAS:
- 36508-71-1
- MF:
- C34H36ClN3O10
- MW:
- 682.12
- EINECS:
- 253-076-4
- Mol File:
- 36508-71-1.mol
ZORUBICIN HCL Chemical Properties
- alpha
- D20 -50° (c = 0.2 in water)
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- Orange to Dark Red
- Stability:
- Light Sensitive
ZORUBICIN HCL Usage And Synthesis
Originator
Zorubicin Hydrochloride,ZYF Pharm Chemical
Uses
Zorubicin Hydrochloride is an anthracycline anti-cancer drug related to Daunorubicin (D194500).
Uses
Antineoplastic.
Manufacturing Process
9.024 g daunorubicin-hydrochloride (its preparation and physicochemical properties have been described in British Patent Specification No 985 598) was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162 g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained precipitate was filtered off, washed with 100 ml of ethanol and dried in vacuum at 20°C. It was dissolved in water and small quantity of insoluble product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6- trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12- trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide dihydrochloride (zorubicin) was obtained as red-orange crystalline powder; [α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form of different non-toxic salts such as benzoates, fumarates, maleates, tartrates and so on. The best among these compounds proves to be daunorubicin benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No. 1,578,722 published in 1967, Class CO7d).
Therapeutic Function
Antineoplastic, Antileukemic
ZORUBICIN HCL Preparation Products And Raw materials
Raw materials
ZORUBICIN HCLSupplier
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ZORUBICIN HCL(36508-71-1)Related Product Information
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- 3-Dechloro-3-broMo Trazodone Hydrochloride
- 2-[3-[4-(3-chloro-4-ethylphenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
- 1,2-Ethanediamine, N,N,N',N'-tetrakis(2-aminoethyl)-
- Halofuginone Hydrochloride
- Zorubicin
- D-LYXOSE
- Daunorubicin
- ZORUBICIN HCL
- L-DaunosamineHCl
- DAUNOSAMINE HYDROCHLORIDE
- 13-Deoxocarminomycin
- Feudomycin A