MRS 1220
MRS 1220 Basic information
- Product Name:
- MRS 1220
- Synonyms:
-
- 9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE
- N-[9-CHLORO-2-(2-FURANYL)[1,2,4]-TRIAZOLO[1,5-C]QUINAZOLIN-5-YL]BENZENE ACETAMIDE
- MRS 1220
- 9-chloro-2-(2-furanyl)-5-((phenylacetyl)amino)-[1,2,4]triazolo[1,5-c]quinazoline
- MRS 1220;9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE;N-[9-CHLORO-2-(2-FURANYL)[1,2,4]-TRIAZOLO[1,5-C]QUINAZOLIN-5-YL]BENZENE ACETAMIDE;MRS 1220;9-CHLORO-2-(2-FURANYL)-5-((PHENYLACETYL)AMINO)-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLINE
- 9-CHLORO-2-(2-FURANYL)-5-((PHENYLACETYL)AMINO)-[1,2,4]TRIAZOLO[1,5-C]QUINA
- MRS 1220;9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE;N-[9-CHLORO-2-(2-FURANYL)[1,2,4]-TRIAZOLO[1,5-C]QUINAZOLIN-5-YL]BENZENE ACETAMIDE;MRS 1220;9-CHLORO-2-(2-FURANYL)-5-((PHENYLACETYL)AMINO)-[1,2,4]TRIAZOLO[1,5-C]QUINA
- Benzeneacetamide, N-[9-chloro-2-(2-furanyl)[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-
- CAS:
- 183721-15-5
- MF:
- C21H14ClN5O2
- MW:
- 403.82
- Mol File:
- 183721-15-5.mol
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MRS 1220 Chemical Properties
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: 2 mg/mL
- form
- solid
- pka
- 8.17±0.46(Predicted)
- color
- white
MSDS
- Language:English Provider:SigmaAldrich
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MRS 1220 Usage And Synthesis
Uses
MRS 1220 is a highly potent and selective human Adenosine A3-R antagonist.
Definition
ChEBI: N-[9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylacetamide is a member of quinazolines.
Biological Activity
A potent and highly selective antagonist at the human A 3 adenosine receptor (K i values are 0.65, 305, and 52 nM at hA 3 , rA 1 and rA 2A respectively. Displays an IC 50 value > 1 μ M for inhibition of binding to rat A 3 receptors).
in vivo
MRS1220 (0.15 mg/kg; intraperitoneal inoculation) reduces tumor size and blood vessel formation in vivo. MRS1220 exhibits a strong in vivo anti-angiogenic effect[2].
| Animal Model: | Eight, 8 week-old male Sprague-Dawley rats bearing C6 (GSCs)[2] |
| Dosage: | 0.15 mg/kg/72 h |
| Administration: | Administered by intraperitoneal inoculation, for fifteen days |
| Result: | A reduction close to 80% and 90% in tumor volume compared to the vehicle-treated group at day ten and fifteen post-treatment, respectively. |
storage
Store at RT
MRS 1220Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
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Nanjing Chemlin Chemical Co., Ltd
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- 025-83697070
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EMMX Biotechnology LLC
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- 888-539-0666
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Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Shanghai Rechem science Co., Ltd.
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- 021-31433387 15618786686
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