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LARIXYL ACETATE

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LARIXYL ACETATE Basic information

Product Name:
LARIXYL ACETATE
Synonyms:
  • LARIXYL ACETATE
  • (13S)-6α-Acetoxylabda-8(17),14-diene-13-ol
  • (1S,8aβ)-4α-[(S)-3-Methyl-3-hydroxy-4-pentenyl]decahydro-4aα,8,8-trimethyl-3-methylenenaphthalen-1β-ol 1-acetate
  • (1S,8aβ)-4α-[(S)-3-Methyl-3-hydroxy-4-pentenyl]decahydro-4aα,8,8-trimethyl-3-methylenenaphthalene-1β-ol 1-acetate
  • [13S,(+)]-Labda-8(17),14-diene-6α,13-diol 6-acetate
  • 6-Acetyllarixol
  • (αS,1S,4S,4aS,8aR)-4-(Acetyloxy)-α-ethenyldecahydro-α,5,5,8a-tetramethyl-2-methylene-1-naphthalenepropanol
  • Larixyl acetate (Larix-6-yl monoacetate)
CAS:
4608-49-5
MF:
C22H36O3
MW:
348.52
Mol File:
4608-49-5.mol
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LARIXYL ACETATE Chemical Properties

Melting point:
82℃
Boiling point:
419.3±28.0 °C(Predicted)
Density 
1.00±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.4826 (589.3 nm, 20℃)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
14.47±0.29(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
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Safety Information

WGK Germany 
3
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LARIXYL ACETATE Usage And Synthesis

Uses

Larixyl Acetate has pharmacological activity determined though in vitro anti-inflammatory activity of larch (Larix decidua L.) sawdust (Erratum).

in vivo

Larixyl acetate (5 mg/kg, i.p., once dailly for 7 days) significantly improves aortic endothelial dysfunction in TBI mice by inhibiting TRPC6 activity, particularly enhancing acetylcholine-induced dilation[3]. Larixyl acetate (5 mg/kg, i.p., once daily for 4 weeks) improves cardiac function in pressure overload-induced heart failure model by inhibiting TRPC6, reducing cardiac hypertrophy, fibrosis, and apoptosis[4].

Animal Model:Closed-head mild traumatic brain injury (mTBI) model, C57BL/6, 129S, 129S-C57BL/6-F2 mice, TRPC6 knockout mice[3]
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.), once daily for 7 days
Result:Significantly improved aortic endothelial function 7 days after TBI. Caused that acetylcholine (10 μM) induced dilation was significantly enhanced in Larixyl acetate-treated mice (In C57BL/6 mice, the Larixyl acetate group showed 96.9 %; in 129S-C57BL/6-F2 mice, the Larixyl acetate group showed 89.2 %).
Animal Model:Transverse aortic constriction (Tac) model for pressure overload-induced heart failure in mice[5]
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.), once daily for 4 weeks
Result:Significantly reduced cardiac hypertrophy, left ventricular pressure, and improved cardiac function (FS and EF increased). Improved TAC-induced cardiac fibrosis, cardiomyocyte apoptosis, and inhibited ER stress-related proteins (e.g., GRP78) expression.

IC 50

hTRPC6: 0.58 μM (IC50); hTRPC3: 6.83 μM (IC50)

LARIXYL ACETATESupplier

Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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cwb1@biopurify.cn
Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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3003855609@qq.com
Wuxi Zhongkun Biochemical Technology Co., Ltd.
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0510-85629785 18013409632
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sales@reading-chemicals.com
Wuhan ChemFaces Biochemical Co., Ltd.
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18607101326 15172504745
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aileen@chemfaces.com
EMMX Biotechnology LLC
Tel
888-539-0666
Email
info@emmx.com
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