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Ceftriaxone sodium

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Ceftriaxone sodium Basic information

Product Name:
Ceftriaxone sodium
Synonyms:
  • (6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate
  • Ceftriaxone sodiuM sesquaterhydrate
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:4:7), (6R,7R)-
  • Ceftriaxone SodiuM Trihydrate
  • Ceftriaxone disodium salt hemiheptahydrate, >=98%
  • sodium 7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:
  • Ceftriaxone (sodium salt hydrate)
CAS:
104376-79-6
MF:
C18H21N8NaO8S3
MW:
596.58
EINECS:
626-956-4
Product Categories:
  • VESPRIN
  • Antibiotics for Research and Experimental Use
  • API
  • beta-Lactams (Antibiotics for Research and Experimental Use)
  • Biochemistry
  • Antibiotic Explorer
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • A - KAntibiotics
  • Antibacterial
  • Antibiotics A to
  • Antibiotics A-FAntibiotics
  • Chemical Structure Class
  • Interferes with Cell Wall SynthesisAntibiotics
  • Mechanism of Action
  • Penicillins and Cephalosporins (beta-Lactams)
  • Spectrum of Activity
  • Ceftriaxone
  • Heterocycles
  • Sulfur & Selenium Compounds
Mol File:
104376-79-6.mol
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Ceftriaxone sodium Chemical Properties

Melting point:
236 °C
alpha 
D25 -165° (c = 1 in water) (calc for water-free substance)
refractive index 
-160 ° (C=1, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: soluble50mg/mL
pka
~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH)
form 
powder or crystals
color 
White to Off-White
Water Solubility 
Freely soluble in water
InChIKey
FDRNWTJTHBSPMW-BBJOQENWSA-L
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Safety Information

Hazard Codes 
Xn
Risk Statements 
36/37/38-42/43
Safety Statements 
26-36-45-37-24-22
WGK Germany 
1
RTECS 
XI0368800
HS Code 
29349990
Toxicity
LD50 in male, female, mice, rats (mg/kg): 3000, 2800, 2175, 2175 i.v.; >10000 all species orally; >5000 all species s.c. (Teelman)

MSDS

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Ceftriaxone sodium Usage And Synthesis

Description

Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models.

Chemical Properties

White Crystalline Solid

Uses

antipsychotic

Uses

A potentially useful antibacterial agent for proteomics research.

Uses

An antibacterial, a third-generation cephalosporin.

Definition

ChEBI: Ceftriaxone disodium salt hemiheptahydrate is a cephalosporin.

brand name

Rocephin (Roche).

Biological Activity

β -lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.

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