2,6-Dichlorophenylhydrazine hydrochloride Chemical Properties

Melting point:

225 °C (dec.)(lit.)

Boiling point:

346.49°C (rough estimate)

Density 

1.6100 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

color 

White to Light yellow to Light orange

BRN 

4569738

CAS DataBase Reference

50709-36-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xi,Xn

Risk Statements 

20/21-25-36/37/38-20/21/22

Safety Statements 

26-36/37/39-45-22

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29280000

MSDS

• Language:English Provider:2,6-Dichlorophenylhydrazine hydrochloride
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2,6-Dichlorophenylhydrazine hydrochloride Usage And Synthesis

Chemical Properties

white to light yellow powder

Uses

(2,6-Dichlorophenyl)hydrazine Hydrochloride

Uses

2,6-Dichlorophenylhydrazine hydrochloride was used in the preparation of 1-(2,6-dichlorophenyl)-4-methyl-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid, ethyl ester.

Synthesis

General procedure for the synthesis of 2,6-dichlorophenylhydrazine hydrochloride from 2,6-dichloroaniline: 2,6-dichloroaniline (10.0 g, 61.72 mmol) was dissolved in an appropriate amount of solvent and cooled to -15 °C. At this temperature, aqueous sodium nitrite (5.11 g, 74.00 mmol) and hydrochloric acid were slowly added. The reaction mixture was stirred at 0-10°C for 15 minutes. The reaction mixture was filtered to remove insoluble matter and subsequently concentrated hydrochloric acid (34.7 g, 150 mmol) was added to the filtrate. The reaction system was maintained at -15 °C and stirring was continued for 30 min, after which the precipitate was collected by filtration to afford 15.00 g of the target product 2,6-dichlorophenylhydrazine hydrochloride. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 7.18-7.28 (m, 1H), 7.39-7.52 (m, 2H), 10.30 (br s, 3H); the mass spectrum (MS) showed m/z: 176.90 (M)+.

References

[1] Patent: WO2013/186692, 2013, A1. Location in patent: Page/Page column 103; 104

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