ETHYL 2-FLUOROBENZOATE Chemical Properties

Boiling point:

115 °C

Density 

1.15

refractive index 

1.493

Flash point:

217-220°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light orange to Yellow

Specific Gravity

1.15

BRN 

2084296

CAS DataBase Reference

443-26-5(CAS DataBase Reference)

EPA Substance Registry System

Benzoic acid, 2-fluoro-, ethyl ester (443-26-5)

Safety Information

Hazard Codes 

F

Safety Statements 

24/25

Hazard Note 

Flammable

TSCA 

Yes

HS Code 

29163990

MSDS

• Language:English Provider:ALFA

ETHYL 2-FLUOROBENZOATE Usage And Synthesis

Chemical Properties

Clear colorless to yellow liquid

Synthesis

General procedure for the synthesis of ethyl o-fluorobenzoate from o-fluoroiodobenzene and potassium 2-ethoxy-2-oxoacetate: Palladium catalyst (1 mol%) and potassium 2-ethoxy-2-oxoacetate (0.75 mmol) were added to an oven-dried Schlenk tube (10 mL). The Schlenk tube was evacuated and backfilled with argon (this process was repeated three times). Subsequently, o-fluoroiodobenzene (0.5 mmol) and N-methylpyrrolidone (NMP, 1.0 mL) were added via syringe at room temperature under argon protection. After sealing the reaction vessel, it was placed in a preheated oil bath and reacted under stirring for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate and analyzed by gas chromatography.

References

[1] Tetrahedron Letters, 2012, vol. 53, # 43, p. 5796 - 5799

ETHYL 2-FLUOROBENZOATE(443-26-5)Related Product Information

• 2-Fluorobenzoic acid
• 2-Fluoropropiophenone
• 2-Chlorobenzyl alcohol
• 2-Fluorobenzaldehyde
• 2-Bromofluorobenzene
• 2-Chlorophenylacetic acid
• 2-Chloromandelic acid
• 2-Fluorobenzonitrile
• 2-Fluorophenylacetic acid
• 2'-Fluoroacetophenone
• 2-Chlorobenzonitrile
• 2'-Chloroacetophenone
• 2-Chlorobenzyl bromide
• 1-Fluoro-2-nitrobenzene
• 2-Chlorobenzaldehyde
• METHYL 2-FLUOROBENZOATE
• ETHYL 2,4-DIFLUOROBENZOATE
• Ethyl benzoate