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GLYCINE ANHYDRIDE

Basic information Safety Supplier Related

GLYCINE ANHYDRIDE Basic information

Product Name:
GLYCINE ANHYDRIDE
Synonyms:
  • PIPERAZINE-2,5-DIONE
  • Glycine EP Impurity B
  • Oxiracetam-1
  • OXIRACETAM-1
  • 2,5-Dioxopiperazin
  • 2,5-Dioxopiperazine lactam
  • 2,5-Piperazindion
  • alpha,gamma-Diacipiperazine
CAS:
106-57-0
MF:
C4H6N2O2
MW:
114.1
EINECS:
203-411-5
Mol File:
106-57-0.mol
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GLYCINE ANHYDRIDE Chemical Properties

Melting point:
>300 °C(lit.)
Boiling point:
213.59°C (rough estimate)
Density 
1.3565 (rough estimate)
refractive index 
1.4487 (estimate)
storage temp. 
Store below +30°C.
solubility 
142g/l
pka
12.88±0.20(Predicted)
form 
Crystalline Powder
color 
White to slightly yellow
Water Solubility 
Soluble in water (142mg/L).
Merck 
14,7466
BRN 
112112
InChIKey
BXRNXXXXHLBUKK-UHFFFAOYSA-N
CAS DataBase Reference
106-57-0(CAS DataBase Reference)
EPA Substance Registry System
2,5-Piperazinedione (106-57-0)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
RTECS 
TL6325250
TSCA 
Yes
HS Code 
29335990

MSDS

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GLYCINE ANHYDRIDE Usage And Synthesis

Chemical Properties

white to slightly yellow crystalline powder

Definition

ChEBI: A cyclic peptide that is piperazine in which the hydrogens at positions 2 and 5 are replaced by oxo groups.

Synthesis Reference(s)

Journal of the American Chemical Society, 87, p. 4646, 1965 DOI: 10.1021/ja00948a047

Purification Methods

Recrystallise glycine anhydride from H2O (plates) and it can be sublimed (slowly) at 260o or at 140-170o/0.5mm. The dihydrochloride has m 129-130o and is prepared by dissolving it in conc HCl and adding EtOH to crystallisation point; dry it in a vacuum. The bis-1-naphthylurethane has m 232o(dec), and the diperchlorate has m 117o (hygroscopic). [MS: Johnstone J Chem Soc, Perkin Trans 1 1297 1975, NMR: Blaha & Samek Collect Czech Chem Commun 32 3780 1967, Sauborn J Phys Chem 36 179 1932, Corey J Am Chem Soc 60 1599 1938, Beilstein 24 IV 1070.]

GLYCINE ANHYDRIDE Preparation Products And Raw materials

Preparation Products

GLYCINE ANHYDRIDESupplier

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