5-HEXYNOIC ACID Chemical Properties

Melting point:

27°C (estimate)

Boiling point:

224-225 °C(lit.)

Density 

1.016 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.449(lit.)

Flash point:

230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Acetonitrile: Soluble: =10 mg/ml
Methanol: Soluble: =10 mg/ml

pka

4?+-.0.10(Predicted)

form 

Liquid

color 

yellow

Water Solubility 

Miscible with water.

BRN 

1743192

InChI

InChI=1S/C6H8O2/c1-2-3-4-5-6(7)8/h1H,3-5H2,(H,7,8)

InChIKey

VPFMEXRVUOPYRG-UHFFFAOYSA-N

SMILES

C(O)(=O)CCCC#C

CAS DataBase Reference

53293-00-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

3265

WGK Germany 

3

F 

10-23

HazardClass 

8

PackingGroup 

III

HS Code 

29161900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-HEXYNOIC ACID Usage And Synthesis

Chemical Properties

clear yellow liquid

Uses

5-Hexynoic acid is used in the preparation of hex-5-ynoic acid methyl ester by using p-toluenesulfonic acid as a reagent. It is also involved in chemical synthesis.

Definition

ChEBI: A hexynoic acid in which the triple bond is between the carbons at positions 5 and 6.

General Description

5-Hexynoic acid is an alkynoic acid. It undergoes gold-catalyzed cyclization to form the corresponding methylene lactones.

References

[1] KRITHIKA P KARTHIGEYAN. A bioorthogonal chemical reporter for fatty acid synthase-dependent protein acylation.[J]. The Journal of Biological Chemistry, 2021: 101272. DOI: 10.1016/j.jbc.2021.101272

5-HEXYNOIC ACID(53293-00-8)Related Product Information

• METHYL 5-HEXYNOATE
• 5,8,11-EICOSATRIYNOIC ACID
• 5,7-OCTADECADIYNOIC ACID
• 5,7-EICOSADIYNOIC ACID
• 5-HEXYNOIC ACID
• 2-HEXYNOIC ACID METHYL ESTER
• 2-HEXYNOIC ACID
• 2-Hexynoic acid ethyl ester
• FMOC-(S)-3-AMINO-5-HEXYNOIC ACID,N-(9-FLUORENYLMETHOXYCARBONYL)-(S)-3-AMINO-5-HEXYNOIC ACID
• 5,7-HEXADECADIYNOIC ACID
• 5,7-DOCOSADIYNOIC ACID
• (S)-3-AMINO-5-HEXYNOIC ACID HCL
• 5,7-DODECADIYNEDIOIC ACID
• 5,6-DEHYDROARACHIDONIC ACID
• ETYA
• 4-AMINO-5-HEXYNOIC ACID
• BOC-(S)-3-AMINO-5-HEXYNOIC ACID,N-T-BUTOXYCARBONYL-(S)-3-AMINO-5-HEXYNOIC ACID
• N-(9-FLUORENYLMETHOXYCARBONYL)-(R)-3-AMINO-5-HEXYNOIC ACID,FMOC-(R)-3-AMINO-5-HEXYNOIC ACID