Phosalone Chemical Properties

Melting point:

47.5-48°

Boiling point:

446.7±55.0 °C(Predicted)

Density 

1.39 g/cm3

vapor pressure 

<6×10^-5 Pa (25 °C)

Flash point:

100 °C

storage temp. 

0-6°C

solubility 

DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

pka

-1.75±0.20(Predicted)

Water Solubility 

3.05 mg l^-1 (25°C)

form 

solid

color 

Crystals

Odor

garlic odor

BRN 

694650

Stability:

Hygroscopic

InChIKey

IOUNQDKNJZEDEP-UHFFFAOYSA-N

CAS DataBase Reference

2310-17-0(CAS DataBase Reference)

NIST Chemistry Reference

Phosalone(2310-17-0)

EPA Substance Registry System

Phosalone (2310-17-0)

Safety Information

Hazard Codes 

T,N

Risk Statements 

21-25-50/53-43-20/21

Safety Statements 

36/37-45-60-61

RIDADR 

2783

WGK Germany 

3

RTECS 

TD5175000

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

2310-17-0(Hazardous Substances Data)

Toxicity

LD50 in mice, female, male rats, guinea pigs (mg/kg): 180-205, 135-170, 120, 82-150 orally; female rats (mg/kg): 390 dermally (Colinese, Terry)

Phosalone Usage And Synthesis

Uses

Insecticide; acaracide

Uses

Phosalone is used to control codling moth, aphids, beetles and thrips on fruit trees

Uses

Phosalone is a organophosphate compouund used as insecticide and acaricide. Phosalone is a weak inhibitor of acetylcholinesterase.

Uses

Insecticide, acaricide.

Definition

ChEBI: A member of the class of 1,3-benzoxazoles carrying a [(diethoxyphosphorothioyl)sulfanyl]methyl group at the nitrogen atom, an oxo group at position 2 and a chloro group at position 6. It is an organothiophosphate insecticide.

Safety Profile

Poison by ingestion, skin contact,and possibly other routes. A cholinesterase inhibitor. Seealso PARATHION. When heated to decomposition itemits very toxic fumes of Cl^-, NOx, POx, and SOx.

Environmental Fate

Plant. Degrades in plants to chlorbenzoxazolone, formaldehyde and diethyl phosphorodithioate (Hartley and Kidd, 1987)
Soil. Ambrosi et al. (1977a) studied the persistence and metabolism of phosalone in both moist and flooded Matapeake loam and Monmouth fine sandy loam. Phosalone rapidly degraded (half-life 3 to 7 days) but mineralization to carbon dioxide accoun
Chemical/Physical. Emits toxic fumes of chlorine, phosphorus, nitrogen and sulfur oxides when heated to decomposition (Sax and Lewis, 1987)

Metabolic pathway

Photodegradation of phosalone in solvent yields dechlorinated phosalone. Irradiation in methanol affords O,O-diethyl-S-methylphosphorothioate and 6- chloro-3-methoxymethyl-2-oxobenzoxazoline with other common products. Photolysis of phosalone in the solid state as a thin film on a glass surface produces a number of photoproducts including 6-chloro-3- mercaptomethyl-2-oxobenzoxazoline and its dimeric disulfide.

Metabolism

Orally administered phosalone in mammals is rapidly degraded by oxidation and hydrolysis to give O,O-diethyl hydrogen phosphorothioate and phosphorodithioate and 6-chloro-2,3-dihydro-2-oxobenzoxazole, which is further metabolized and excreted in the urine. It is strongly adsorbed to soil and rapidly degraded with DT₅₀ values of 1–4 d.

Degradation

Phosalone is hydrolysed by strong acids and alkalis with a DT₅₀, of 9 days at pH 9 (PM).

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