5,6-Dimethylpyridin-2-amine Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Chloroform, Dichloromethane

form 

Solid

color 

Light Yellow

InChI

InChI=1S/C7H10N2/c1-5-3-4-7(8)9-6(5)2/h3-4H,1-2H3,(H2,8,9)

InChIKey

UZAOIPZZPZCFES-UHFFFAOYSA-N

SMILES

C1(N)=NC(C)=C(C)C=C1

CAS DataBase Reference

57963-08-3

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-41-37/38-22

Safety Statements 

26-37/39-39

HS Code 

29339990

5,6-Dimethylpyridin-2-amine Usage And Synthesis

Chemical Properties

Light Yellow Low-Melting Solid

Synthesis

A mixture of 2-amino-5-bromo-6-methylpyridine (561 mg, 3.0 mmol), K2CO3 (1.24 g, 9.0 mmol) and Pd(dppf)Cl2·CH2Cl2 (245 mg, 0.30 mmol) was added to a solution of trimethylboroxine (377 mg, 3.0 mmol) in water (1 mL) and dioxane (10 mL). The mixture was heated at reflux for 3 h. After cooling to rt, the mixture was poured into water (50 mL). The mixture was extracted with diethyl ether (3*50ml), and the combined organic phases were dried (Na2SO4) and concentrated. Purification by chromatography (EtOAc/heptane) gave 5,6-Dimethylpyridin-2-amine as a black-brown solid. Yield: 67 %.

5,6-Dimethylpyridin-2-amine(57963-08-3)Related Product Information

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• 3-IODO-4-AMINO-2,6-DIMETHYLPYRIDINE
• 2-AMINO-6-(4-CHLOROPHENYL)-5-METHYL-4-PHENYLNICOTINONITRILE