4-Bromo-o-xylene Chemical Properties

Melting point:

−12-−10 °C

Boiling point:

215 °C (lit.)

Density 

1.37 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.555(lit.)

Flash point:

177 °F

storage temp. 

Store below +30°C.

form 

clear liquid

color 

Colorless to Light yellow

Specific Gravity

1.37

Water Solubility 

Not miscible in water.

BRN 

2040354

InChI

1S/C8H9Br/c1-6-3-4-8(9)5-7(6)2/h3-5H,1-2H3

InChIKey

QOGHRLGTXVMRLM-UHFFFAOYSA-N

SMILES

Cc1ccc(Br)cc1C

CAS DataBase Reference

583-71-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 4-bromo-1,2-dimethyl-(583-71-1)

EPA Substance Registry System

Benzene, 4-bromo-1,2-dimethyl- (583-71-1)

Safety Information

Hazard Codes 

Xn,N,Xi

Risk Statements 

22-36/37/38-50/53

Safety Statements 

26-60-61-24/25

RIDADR 

UN 1701 6.1/PG 2

WGK Germany 

3

RTECS 

CY9020400

F 

19

Hazard Note 

Irritant

TSCA 

TSCA listed

HazardClass 

9

HS Code 

29036990

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Acute 1
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:3,4-Dimethylbromobenzene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Bromo-o-xylene Usage And Synthesis

Chemical Properties

Clear colourless to light yellow liquid

Uses

4-Bromo-o-xylene is used as synthetic organic materials and soluble polyimide resin intermediates.

Synthesis

A method for the preparation of 4-bromo-1,2-xylene, the method uses o-xylene as raw material, in the presence of dichloromethane solvent and catalyst, dropwise addition of bromine at a temperature of -60 ?? to -20 ??, o-xylene and bromine molar ratio of 1:1, after the dropwise addition is completed, hold the temperature to carry out the reaction, and then slowly raise the temperature to 10-20 ??, to remove the dissolved hydrogen bromide in the reaction solution, add saturated aqueous solution of sodium sulfite , stirring for 30 minutes, the product containing dichloromethane was recovered by layering, and then washed with 5% dilute alkali solution to PH = 8-9, and finally washed with water to neutral, to obtain colorless or light yellow 4-bromo-1,2-xylene crude product, distillation under atmospheric pressure to recover solvent dichloromethane, and then distillation under reduced pressure to obtain 4-bromo-1,2-xylene product, said catalyst is a mixture of ferric chloride and quaternary ammonium salt, and the catalyst is a mixture of ferric chloride and quaternary ammonium salt. The quaternary ammonium salt is for example: tetrabutyl ammonium chloride, tetrabutyl ammonium bromide, tetrapropyl ammonium bromide, methyltrioctyl ammonium chloride, benzyltriethylammonium chloride, and the mass ratio of ferric trichloride and the quaternary ammonium salt is 4-5:1. The content of the obtained 4-bromo-1,2-xylene is increased to 85-93%, and at the same time, the content of the byproduct is reduced, and the yield of the product is increased to 95%. Duration of bromine addition: 3-4 h. Holding time of reaction: 2 h. Temperature of alkaline washing: room temperature.

4-Bromo-o-xylene(583-71-1)Related Product Information

• Xylene
• 3-Bromoanisole
• 4'-Bromopropiophenone
• 2-Bromofluorobenzene
• o-Xylene
• Bromoxynil
• 4-Bromotoluene
• 4-Bromoveratrole
• Musk xylene
• 4-Bromobenzaldehyde
• m-Xylene
• Bromoxynil octanoate
• Sodium xylenesulfonate
• 2,3-Dimethylbenzaldehyde
• 5-[1-(2,3-DiMethylphenyl)ethenyl]iMidazole
• 2-(1-chloroethyl)-1,4-dimethylbenzene
• Medetomidine Impurity 54
• à-bromo-m-xylene,α-bromo-m-xylene,α-Bromo-m-xylene ,96%,A-BROMO-M-XYLENE,ALPHA-BROMO-M-XYLENE,omega-bromo-m-xylen