1-METHANESULFONYL-PIPERAZINE Chemical Properties

Melting point:

99 °C

Boiling point:

280.6±50.0 °C(Predicted)

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

7.78±0.10(Predicted)

form 

Solid

color 

White to Almost white

Water Solubility 

Slightly soluble in water.

CAS DataBase Reference

55276-43-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36/37/39-24/25-23

HazardClass 

IRRITANT

HS Code 

29339900

1-METHANESULFONYL-PIPERAZINE Usage And Synthesis

Chemical Properties

White solid

Uses

1-(Methylsulfonyl)piperazine is employed as a intermediate for pharmaceutical and chemical research.

Synthesis

Step 2: Synthesis of 1-(methylsulfonyl)piperazine A mixture of tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate (1.0 g, 3.79 mmol) with trifluoroacetic acid (TFA, 0.86 g, 7.58 mmol) in dichloromethane (CH2Cl2, 10 mL) was stirred for 2 hours at room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure to afford 1-(methylsulfonyl)piperazine as a yellow oil (0.5 g, 80.52% yield). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 3.50-3.47 (m, 4H), 3.33-3.28 (m, 4H), 2.92 (s, 3H); ESI-MS m/z: 165 ([M + H]+).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 1, p. 375 - 379
[2] Patent: WO2010/141538, 2010, A1. Location in patent: Page/Page column 23
[3] Patent: WO2004/43950, 2004, A1. Location in patent: Page 152
[4] Patent: WO2005/51957, 2005, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2004/85425, 2004, A1. Location in patent: Page 98

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