2-Diethylaminoethylchloride hydrochloride Chemical Properties

Melting point:

50-53 °C(lit.)

Boiling point:

255 °C(lit.)

Density 

1.1919 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.6000 (estimate)

Flash point:

186 °F

storage temp. 

Poison room

solubility 

methanol: 0.1 g/mL, clear, colorless

form 

Crystalline Powder

color 

White to slightly beige

PH

5 (100g/l, H2O, 20℃)

Water Solubility 

2000 g/L (20 ºC)

Sensitive 

Moisture Sensitive

BRN 

3591991

Stability:

Hygroscopic, Moisture Sensitive

InChIKey

RAGSWDIQBBZLLL-UHFFFAOYSA-N

CAS DataBase Reference

869-24-9(CAS DataBase Reference)

EPA Substance Registry System

Diethyl-(2-chloroethyl)amine hydrochloride (869-24-9)

Safety Information

Hazard Codes 

Xn,T,Xi,T+

Risk Statements 

22-36/37/38-26-24/25-23/24/25

Safety Statements 

26-36-45-36/37/39-28A

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

DC2810000

Hazard Note 

Irritant/Very Toxic

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29211980

Hazardous Substances Data

869-24-9(Hazardous Substances Data)

MSDS

• Language:English Provider:2-Diethylaminoethylchloride hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
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2-Diethylaminoethylchloride hydrochloride Usage And Synthesis

Chemical Properties

2-Diethylaminoethylchloride hydrochloride is colourless to beige crystals

Uses

2-Chloro-N,N-diethylethylamine hydrochloride (65% in water) (DEC 65) is used as intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl). Product Data Sheet

Uses

2-Chloro-N,N-diethylethylamine hydrochloride can be used as an alkylating reagent for the synthesis of:

• Substituted oxindole derivatives to be used as growth hormone secretagogs.
• 1-Substituted-5,6-dinitrobenzimidazoles with antimicrobial and antiprotozoal activities.
• Thiophene containing triarylmethane (TRAM) derivatives to be used as antitubercular agents.
• Tris(2-(diethylamino)ethyl)amine to be used as a catalyst in combination with CuBr (Et₆TREN/CuBr) for atom transfer radical polymerization of n-butyl acrylate.

It can also be used for the derivatization of chitosan to incorporate aminofunctionality onto it at C-6 position.

Uses

2-Diethylaminoethylchloride hydrochloride is used as intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl). Product Data Sheet

Purification Methods

Crystallise the salt from absolute MeOH (to remove highly coloured impurities). [Beilstein 4 III 240.]

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